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Guidelines

MIRAGE

protein O-fucosyltransferase 1

Summary

Gene Symbol

POFUT1

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 449504
KEGG Gene ID: ptr:449504
PubChem: 449504

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Manganese
Notch signaling pathway
Reference proteome
Signal
Transferase

Proteins

Displaying **all 3** entries
UniProt	Protein Name
K7BC39	Peptide-O-fucosyltransferase 1
A0A663DFW6	Peptide-O-fucosyltransferase 1
Q6EV69	Peptide-O-fucosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
angiogenesis
somitogenesis
fucose metabolic process
protein O-linked glycosylation
Notch signaling pathway	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202
membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fucosyltransferase activity
peptide-O-fucosyltransferase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDP-fucose protein o-fucosyltransferase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fucose metabolic process
peptide-O-fucosyltransferase activity
protein O-linked fucosylation
transferase activity

Displaying **all 2** entries
InterPro
GDP-fucose protein O-fucosyltransferase 1
GDP-fucose protein O-fucosyltransferase

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23509		HUMAN56471
Mus musculus	140484		MOUSE31766
Rattus norvegicus	311551		RATNO28480
Bos taurus	360194		BOVIN05066
Sus scrofa	397627		PIGXX11559
Danio rerio	403029		DANRE24095
Canis lupus familiaris	609881		CANLF09433
Macaca mulatta	711966		MACMU01997
Monodelphis domestica	100010283		MONDO01670
Equus caballus	100068638		HORSE21466

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025