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angiotensin I converting enzyme

Summary

Gene Symbol

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 449567
KEGG Gene ID: ptr:449567
PubChem: 449567

Annotation

Keyword

Alternative promoter usage
Calmodulin-binding
Carboxypeptidase
Cell membrane
Cytoplasm
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
H2QZH0
Q9GLN7	Dipeptidyl carboxypeptidase I Kininase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 27 in total

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GO Term	Evidence Code	PMID
hormone metabolic process
regulation of synaptic plasticity
cell proliferation in bone marrow
posttranscriptional regulation of gene expression
kidney development

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

catabolic process [inference]

hormone catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

cell population proliferation [inference]

cell proliferation in bone marrow

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

bradykinin catabolic process

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

icosanoid secretion [inference]

arachidonic acid secretion

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of angiotensin metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

regulation of hematopoietic stem cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane
plasma membrane	IEA	30032202
endosome
extracellular region
lysosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
tripeptidyl-peptidase activity
metal ion binding
bradykinin receptor binding
metalloendopeptidase activity
metallopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

calmodulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

ion binding [inference]

anion binding [inference]

chloride ion binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

angiotensin-converting enzyme isoform 1 precursor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **31 - 39** of 39 in total

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Gene Ontology
regulation of blood pressure
regulation of heart rate by cardiac conduction
regulation of hematopoietic stem cell proliferation
regulation of synaptic plasticity
regulation of systemic arterial blood pressure by renin-angiotensin
spermatogenesis
substance P catabolic process
tripeptidyl-peptidase activity
zinc ion binding

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

KEGG BRITE Database

Orthology

K01283

Name

peptidyl-dipeptidase A [EC:3.4.15.1]

References

Rhea

RHEA:63560

angiotensin I + H₂O

L-histidyl-L-leucine + angiotensin II

Enzyme

3.4.15.1

PMID

10969042

Ortholog

Displaying entries **1 - 10** of 24 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	1636	9606_0:0016f2
Equus caballus	100064801		HORSE04640
Pongo abelii	100453403	9601_0:004392
Nomascus leucogenys	100592115		NOMLE16246
Pan paniscus	100980711	9597_0:00435d	PANPA17686
Saimiri boliviensis boliviensis	101052117		SAIBB36499
Gorilla gorilla gorilla	101145787	9595_0:001bfc
Heterocephalus glaber	101701835		HETGA12181
Chinchilla lanigera	102027972		CHILA17794
Macaca fascicularis	102128376		MACFA14505

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements