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C-X-C motif chemokine receptor 4

Summary

Gene Symbol

CXCR4

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 450130
PubChem: 450130

Annotation

Keyword

Cell junction
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Isopeptide bond
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Sulfation
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
K7DTL4
A0A663D9N7
P61072	Fusin Stromal cell-derived factor 1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
immune response	IEA	30032202
G protein-coupled receptor signaling pathway	IEA	22301074
positive regulation of cytosolic calcium ion concentration	IEA	30032202
brain development	IEA	30032202
calcium-mediated signaling	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lysosome
early endosome
late endosome
plasma membrane
external side of plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
C-C chemokine receptor activity	IEA	30032202
C-C chemokine binding	IEA	30032202
C-X-C motif chemokine 12 receptor activity

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-X-C chemokine receptor type 4-A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **41 - 50** of 93 in total

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Species	Gene ID	Orthologous MAtrix
Ficedula albicollis	101817227	FICAL03076
Melopsittacus undulatus	101875800	MELUD00292
Ictidomys tridecemlineatus	101956113	ICTTR10123
Chinchilla lanigera	102011479	CHILA10991
Macaca fascicularis	102142487	MACFA05007
Capra hircus	102169916	CAPHI20723
Latimeria chalumnae	102361208	LATCH06330
Myotis lucifugus	102427675	MYOLU12726
Vicugna pacos	102542727	VICPA04609
Petromyzon marinus	103091770	PETMA08924

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Acknowledgements