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cytochrome c oxidase subunit I

Summary

Gene Symbol

COX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4512

PubChem

4512

Alliance of Genome Resources

HGNC:7419

JoGo

COX1

TogoVar

COX1

Annotation

Keyword

3D-structure
Calcium
Copper
Disease variant
Heme
Leber hereditary optic neuropathy
Magnesium
Mitochondrion inner membrane
Non-syndromic deafness
Proteomics identification
Reference proteome
Respiratory chain
Sodium
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P00395	Cytochrome c oxidase polypeptide I
U5YWV7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
response to oxidative stress	IEA
aerobic respiration	IBA
electron transport coupled proton transport

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to copper ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	HTP	34800366
mitochondrial inner membrane	TAS
mitochondrial membrane	IDA	30030519
respiratory chain complex IV	IDA	1651240 23168492
respiratory chain complex IV	IMP	19393246

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

respiratory chain complex [inference]

respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytochrome-c oxidase activity	IMP	12140182
cytochrome-c oxidase activity	IBA
protein binding	IPI	12762840 23260140 26321642 29154948 33961781
heme binding	IEA
metal ion binding	IEA