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cytochrome P450 family 19 subfamily A member 1

Summary

Gene Symbol

CYP19A1

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 453433
KEGG Gene ID: ptr:453433
PubChem: 453433

Annotation

Keyword

Heme
Monooxygenase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2J8NSX0	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
A0A6D2Y496	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
response to estradiol	IEA	30032202
female gonad development	IEA	30032202

GO Hierarchy

biological process

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
aromatase activity	IEA	30032202
iron ion binding	IEA	22301074
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
V: Defense mechanisms

Displaying **all 10** entries
Gene Ontology
androgen catabolic process
aromatase activity
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
positive regulation of estradiol secretion
response to estradiol

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07434

Name

aromatase [EC:1.14.14.14]

References

2973313

Rhea

RHEA:38191

O₂ + testosterone

H₂O + H⁺ + formate + 17β-estradiol

Enzyme

1.14.14.14

PMID

RHEA:38195

O₂ + androst-4-ene-3,17-dione

H₂O + H⁺ + formate + estrone

Enzyme

1.14.14.14

PMID

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	1588	9606_1:003a28	HUMAN23092
Mus musculus	13075		MOUSE61102
Rattus norvegicus	25147		RATNO40638
Danio rerio	30390		DANRE13628
Bos taurus	281740		BOVIN01347
Sus scrofa	403331		PIGXX14322
Sus scrofa	403332		PIGXX14322
Sus scrofa	403333		PIGXX14322
Canis lupus familiaris	494003		CANLF12514
Macaca mulatta	678697		MACMU42976

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements