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Guidelines

MIRAGE

mannose phosphate isomerase

Summary

Gene Symbol

MPI

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 453748
KEGG Gene ID: ptr:453748
PubChem: 453748

Annotation

Keyword

Acetylation
Cytoplasm
Isomerase
Metal-binding
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A5A6K3	Phosphohexomutase Phosphomannose isomerase
A0A2J8KRY2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA	22301074
GDP-mannose biosynthetic process	IEA	22301074 30032202
mannose to fructose-6-phosphate metabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process [inference]

mannose to fructose-6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose metabolic process [inference]

GDP-mannose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mannose-6-phosphate isomerase activity	IEA	22301074 30032202
zinc ion binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, interconverting aldoses and ketoses [inference]

mannose-6-phosphate isomerase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mannose-6-phosphate isomerase

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
GDP-mannose biosynthetic process
isomerase activity
mannose-6-phosphate isomerase activity
metal ion binding
zinc ion binding

Displaying **all 8** entries
InterPro
Mannose-6-phosphate isomerase, type I
Mannose-6-phosphate isomerase
Phosphomannose isomerase type I, C-terminal domain
Phosphomannose isomerase type I, catalytic domain
Phosphomannose isomerase type I, helical insertion domain
Phosphomannose isomerase, type I, conserved site
RmlC-like cupin domain superfamily
RmlC-like jelly roll fold

KEGG BRITE Database

Orthology

K01809

Name

mannose-6-phosphate isomerase [EC:5.3.1.8]

References

6397402

Rhea

D-mannose 6-phosphate

D-fructose 6-phosphate

Enzyme

5.3.1.8

PMID

Ortholog

Displaying entries **11 - 20** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100179626		CIOIN04610
Oryctolagus cuniculus	100346668		RABIT15903
Callithrix jacchus	100400555		CALJA00308
Pongo abelii	100461189		PONAB09625
Ailuropoda melanoleuca	100471776		AILME08963
Nomascus leucogenys	100587623		NOMLE31818
Loxodonta africana	100667321		LOXAF10636
Oreochromis niloticus	100692107		ORENI67985
Cavia porcellus	100713995		CAVPO21823
Cricetulus griseus	100764596		CRIGR21595

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025