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tripartite motif containing 37

Summary

Gene Symbol

TRIM37

Organism

Homo sapiens (human)

External Links

NCBI Gene

4591

PubChem

4591

Alliance of Genome Resources

HGNC:7523

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosome
Coiled coil
Cytoplasm
Dwarfism
Membrane
Peroxisome
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome
Repressor
Transcription
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
O94972	Mulibrey nanism protein RING-type E3 ubiquitin transferase TRIM37 Tripartite motif-containing protein 37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II	IDA	25470042
protein monoubiquitination	IDA	28724525
protein monoubiquitination	IBA
protein import into peroxisome matrix	IDA	28724525
negative regulation of NF-kappaB transcription factor activity	IDA	11279055

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization [inference]

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

cellular component assembly [inference]

inclusion body assembly [inference]

aggresome assembly

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of centriole replication [inference]

negative regulation of centriole replication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of centriole replication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of organelle assembly [inference]

regulation of centriole replication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of centriole replication [inference]

negative regulation of centriole replication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of organelle assembly [inference]

negative regulation of centriole replication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of centriole replication [inference]

negative regulation of centriole replication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication [inference]

negative regulation of centriole replication

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromosome	IEA
cytoplasm	IDA	23769972
peroxisome	IDA	11938494
peroxisomal membrane	IDA	28724525
peroxisomal membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

PcG protein complex [inference]

ESC/E(Z) complex

histone methyltransferase complex [inference]

ESC/E(Z) complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex [inference]

ESC/E(Z) complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular non-membrane-bounded organelle [inference]

chromosome

perinuclear region of cytoplasm

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
ubiquitin protein ligase activity	IDA	28724525
ubiquitin protein ligase activity	IBA
histone H2AK119 ubiquitin ligase activity	IDA	25470042

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

histone ubiquitin ligase activity [inference]

histone H2A ubiquitin ligase activity [inference]

histone H2AK119 ubiquitin ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

histone ubiquitin ligase activity [inference]

histone H2A ubiquitin ligase activity [inference]

histone H2AK119 ubiquitin ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

histone ubiquitin ligase activity [inference]

histone H2A ubiquitin ligase activity [inference]

histone H2AK119 ubiquitin ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

histone ubiquitin ligase activity [inference]

histone H2A ubiquitin ligase activity [inference]

histone H2AK119 ubiquitin ligase activity

histone modifying activity [inference]

histone ubiquitin ligase activity [inference]

histone H2A ubiquitin ligase activity [inference]

histone H2AK119 ubiquitin ligase activity

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
negative regulation of centriole replication
protein autoubiquitination
protein ubiquitination
tumor necrosis factor receptor binding
ubiquitin protein ligase binding
zinc ion binding

Displaying **all 5** entries
InterPro
B-box-type zinc finger
MATH/TRAF domain
TRAF-like
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050436	mulibrey nanism	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Cricetulus griseus	100754889	CRIGR11888
Otolemur garnettii	100941587	OTOGA07116
Pan paniscus	100980647	PANPA17606
Papio anubis	101017695	PAPAN13817
Saimiri boliviensis boliviensis	101027755	SAIBB15273
Takifugu rubripes	101071055	TAKRU11571
Felis catus	101095141	FELCA32165
Felis catus	101095387	FELCA32165
Ovis aries	101106605	SHEEP02418
Gorilla gorilla gorilla	101131673	GORGO33757

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements