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3-hydroxyisobutyryl-CoA hydrolase

Summary

Gene Symbol

HIBCH

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 459828
KEGG Gene ID: ptr:459828
PubChem: 459828

Annotation

Keyword

Branched-chain amino acid catabolism
Hydrolase
Mitochondrion
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A6D2XYW8	3-hydroxyisobutyryl-coenzyme A hydrolase
A0A6D2WY78	3-hydroxyisobutyryl-coenzyme A hydrolase
H2QJ54	3-hydroxyisobutyryl-coenzyme A hydrolase
A0A2I3SJ22	3-hydroxyisobutyryl-coenzyme A hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
valine catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
3-hydroxyisobutyryl-CoA hydrolase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

CoA hydrolase activity [inference]

3-hydroxyisobutyryl-CoA hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-hydroxyisobutyryl-coa hydrolase

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
3-hydroxyisobutyryl-CoA hydrolase activity
hydrolase activity
valine catabolic process

Displaying **all 3** entries
InterPro
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase domain
Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type

KEGG BRITE Database

Orthology

K05605

Name

3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4]

References

8824301

Rhea

RHEA:20888

H₂O + 3-hydroxy-2-methylpropanoyl-CoA

3-hydroxy-2-methylpropanoate + H⁺ + CoA

Enzyme

3.1.2.4

PMID

Ortholog

Displaying entries **31 - 40** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Heterocephalus glaber	101725904	HETGA12408
Chrysemys picta bellii	101943533	CHRPI19211
Ictidomys tridecemlineatus	101955292	ICTTR03395
Chinchilla lanigera	102003397	CHILA00462
Capra hircus	102177103	CAPHI21133
Latimeria chalumnae	102350181	LATCH13280
Pelodiscus sinensis	102448296	PELSI08590
Callorhinchus milii	103176535	CALMI10683
Chlorocebus sabaeus	103217520	CHLSB01467
Carlito syrichta	103255999	CARSF28894