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phosphoinositide kinase, FYVE-type zinc finger containing

Summary

Gene Symbol

PIKFYVE

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 459908
KEGG Gene ID: ptr:459908
PubChem: 459908

Annotation

Keyword

ATP-binding
Kinase
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A6D2W211
A0A6D2XTC9
A0A2I3RHI3
H2QJB6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phagosome-lysosome fusion	IEA	30032202
neutrophil chemotaxis	IEA	30032202
regulation of reactive oxygen species biosynthetic process	IEA	30032202
intracellular signal transduction	IEA	22301074
melanosome organization	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

pigment granule organization [inference]

melanosome organization

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
vesicle membrane	IEA	30032202
cytoplasmic vesicle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
1-phosphatidylinositol-3-phosphate 5-kinase activity	IEA	22301074 30032202
metal ion binding	IEA	22301074
ATP binding	IEA	22301074
1-phosphatidylinositol-5-kinase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity [inference]

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

Winged helix-like DNA-binding domain superfamily

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **11 - 20** of 28 in total

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Gene Ontology
nucleotide binding
peptidyl-serine autophosphorylation
phagosome maturation
phagosome-lysosome fusion
phosphatidylinositol 5-phosphate metabolic process
phosphatidylinositol kinase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
phosphatidylinositol-3-phosphate biosynthetic process
phosphorylation
protein serine kinase activity

KEGG BRITE Database

Orthology

K00921

Name

1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]

References

Rhea

RHEA:13609

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)

Enzyme

2.7.1.150

PMID

Ortholog

Displaying entries **51 - 60** of 79 in total

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105467990	MACNE08557
Mandrillus leucophaeus	105549405	MANLE22801
Cercocebus atys	105580121	CERAT00617
Aotus nancymaae	105712852	AOTNA03250
Propithecus coquereli	105823912	PROCO14871
Dipodomys ordii	105985981	DIPOR00288
Equus asinus asinus	106828171	EQUAS23227
Sinocyclocheilus grahami	107569979	SINGR21385
Sinocyclocheilus grahami	107595854	SINGR34042
Rhinopithecus bieti	108540354	RHIBE14456