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phosphoinositide kinase, FYVE-type zinc finger containing

Summary

Gene Symbol

PIKFYVE

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 459908
KEGG Gene ID: ptr:459908
PubChem: 459908

Annotation

Keyword

ATP-binding
Kinase
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A6D2W211
A0A6D2XTC9
A0A2I3RHI3
H2QJB6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
neutrophil chemotaxis	IEA	30032202
melanosome organization	IEA	30032202
intracellular signal transduction	IEA	22301074
phosphatidylinositol metabolic process	IEA	22301074
phagosome-lysosome fusion	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

pigment granule organization [inference]

melanosome organization

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
vesicle membrane	IEA	30032202
cytoplasmic vesicle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
1-phosphatidylinositol-3-phosphate 5-kinase activity	IEA	22301074 30032202
ATP binding	IEA	22301074
metal ion binding	IEA	22301074
1-phosphatidylinositol-5-kinase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity [inference]

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidylinositol 3-phosphate 5-kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
BEACH domain superfamily
BEACH domain

KEGG BRITE Database

Orthology

K00921

Name

1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]

References

Rhea

RHEA:13609

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)

Enzyme

2.7.1.150

PMID

Ortholog

Displaying entries **61 - 70** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Cyprinus carpio carpio	109096325	CYPCA51362
Cyprinus carpio carpio	109096757	CYPCA43916
Crocodylus porosus	109322909	CROPO10293
Phascolarctos cinereus	110223272	PHACI17875
Vulpes vulpes	112922603	VULVU15797
Pseudonaja textilis	113441007	PSETE12945
Bos indicus x Bos taurus	113906996	BOBOX39107
Vombatus ursinus	114051316	VOMUR10408
Podarcis muralis	114581976	PODMU06868
Salmo trutta	115155587	SALTR10113