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calcium voltage-gated channel subunit alpha1 D

Summary

Gene Symbol

CACNA1D

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 460447
PubChem: 460447

Annotation

Keyword

Calcium channel
Disulfide bond
Glycoprotein
Metal-binding
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A6D2W9K8
A0A6D2XM70
A0A2I3TS31
A0A2I3RCA1
A0A6D2W066
A0A2I3SHJ9
A0A2J8P819

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sensory perception of sound
cardiac muscle cell action potential involved in contraction
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane	IEA	30032202
positive regulation of calcium ion transport

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
voltage-gated calcium channel complex	IEA	22301074 30032202
L-type voltage-gated calcium channel complex

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

L-type voltage-gated calcium channel complex

cellular anatomical entity [inference]

membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metal ion binding
voltage-gated calcium channel activity
voltage-gated calcium channel activity involved SA node cell action potential
high voltage-gated calcium channel activity	IEA	30032202
alpha-actinin binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in cardiac muscle cell action potential [inference]

voltage-gated calcium channel activity involved SA node cell action potential

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actinin binding [inference]

alpha-actinin binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

Voltage-dependent calcium channel, L-type, alpha-1D subunit

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 22 in total

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Gene Ontology
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
ankyrin binding
calcium channel activity
calcium ion import
calcium ion transmembrane transport
calcium ion transport
cardiac muscle cell action potential involved in contraction
high voltage-gated calcium channel activity
membrane depolarization during SA node cell action potential
membrane depolarization during cardiac muscle cell action potential

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	776	9606_1:000f0b	HUMAN70588
Mus musculus	12289		MOUSE12795
Rattus norvegicus	29716		RATNO10814
Danio rerio	403310		DANRE03334
Bos taurus	408013		BOVIN17669
Canis lupus familiaris	484724		CANLF07414
Macaca mulatta	693924		MACMU28606
Equus caballus	100051186		HORSE11601
Taeniopygia guttata	100226925		TAEGU03885
Oryctolagus cuniculus	100327259		RABIT12929