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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
MYC proto-oncogene, bHLH transcription factor
Summary
- Gene Symbol
-
- MYC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative initiation
- Alternative splicing
- Chromosomal rearrangement
- Cytoplasm
- DNA-binding
- Glycoprotein
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P01106 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of stress-activated MAPK cascade | ||
| fibroblast apoptotic process | ||
| negative regulation of transcription by RNA polymerase II | ||
| regulation of transcription by RNA polymerase II | ||
| regulation of gene expression |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II transcription repressor complex | ||
| protein-containing complex | ||
| nucleoplasm | ||
| chromatin | ||
| Myc-Max complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| core promoter sequence-specific DNA binding | ||
| transcription regulator activator activity |
|
|
| DNA-binding transcription activator activity, RNA polymerase II-specific | ||
| DNA-binding transcription repressor activity, RNA polymerase II-specific | ||
| SCF ubiquitin ligase complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Myc
- Functional Category
-
- I: Lipid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| protein dimerization activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0001816 | angiosarcoma | |
| DOID:0060318 | acute promyelocytic leukemia | |
| DOID:0080322 | polycystic kidney disease | |
| DOID:0110858 | polycystic kidney disease 1 | |
| DOID:10283 | prostate cancer | |
| DOID:1040 | chronic lymphocytic leukemia | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11132 | prostatic hypertrophy | |
| DOID:11476 | osteoporosis | |
| DOID:127 | leiomyoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 403924 | CANLF03214 | |||
| 448810 | PIGXX22869 | |||
| 464393 | 9598_0:0025f2 | PANTR43255 | ||
| 511077 | BOVIN05732 | |||
| 653028 | TAKRU01644 | |||
| 694626 | MACMU43867 | |||
| 100032344 | MONDO18254 | |||
| 100068097 | HORSE42681 | |||
| 100079391 | ORNAN20873 | |||
| 100219849 | TAEGU18563 |
