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MYD88 innate immune signal transduction adaptor
Summary
- Gene Symbol
-
- MYD88
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Antiviral defense
- Cytoplasm
- Disease variant
- Immunity
- Inflammatory response
- Innate immunity
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A3F2YP85 |
|
| A0A3B3ITY3 |
|
| A0A0A0MSI9 |
|
| Q99836 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| Toll signaling pathway | ||
| induced systemic resistance | ||
| gene expression | ||
| positive regulation of gene expression | ||
| microglia differentiation |
GO Hierarchy
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type I interferon production
- positive regulation of chemokine production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-23 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
biological process
immune system process [inference]
cellular process [inference]
biological process involved in interspecies interaction between organisms [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| Toll binding | ||
| death receptor binding | ||
| interleukin-1 receptor binding | ||
| protein binding |
|
|
| Toll-like receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Myeloid differentiation primary response protein MyD88
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:12253 | testicular lymphoma | |
| DOID:1324 | lung cancer | |
| DOID:234 | colon adenocarcinoma | |
| DOID:3234 | central nervous system lymphoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:612 | primary immunodeficiency disease | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 4615 | Xenbase:XB-GENE-486650 | ||
| 17874 | MOUSE63984 | ||
| 301059 | RATNO41861 | ||
| 396646 | PIGXX03767 | ||
| 403145 | DANRE25567 | ||
| 460269 | PANTR30783 | ||
| 696494 | MACMU29037 | ||
| 100053940 | HORSE10947 | ||
| 100077067 | ORNAN05222 | ||
| 100134853 | TAKRU01618 |
