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myosin heavy chain 9

Summary

Gene Symbol

MYH9

Organism

Homo sapiens (human)

External Links

NCBI Gene

4627

KEGG Gene ID

PubChem

4627

Alliance of Genome Resources

HGNC:7579

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Actin-binding
Alport syndrome
Alternative splicing
Calmodulin-binding
Cataract
Cell adhesion
Cell membrane
Cell shape
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Direct protein sequencing
Disease variant
Host cell receptor for virus entry
Methylation
Myosin
Non-syndromic deafness
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P35579	Cellular myosin heavy chain, type A Myosin heavy chain 9 Myosin heavy chain, non-muscle IIa Non-muscle myosin heavy chain A Non-muscle myosin heavy chain IIa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 43 in total

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GO Term	Evidence Code	PMID
meiotic spindle organization
cell morphogenesis	IEA
angiogenesis	IDA
in utero embryonic development
establishment of T cell polarity

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

meiotic spindle organization

establishment of spindle localization [inference]

establishment of meiotic spindle localization

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of lymphocyte polarity [inference]

establishment of T cell polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis

calcium-ion regulated exocytosis [inference]

cortical granule exocytosis

cell cycle process [inference]

spindle organization [inference]

meiotic spindle organization

cytokinetic process

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

meiotic cell cycle process [inference]

actin filament-based process

actin cytoskeleton organization

actomyosin structure organization

actin filament-based movement

actin-mediated cell contraction [inference]

cytoplasmic actin-based contraction involved in cell motility

cellular developmental process [inference]

cell differentiation

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

platelet formation

endodermal cell differentiation

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration

leukocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization [inference]

spindle organization [inference]

meiotic spindle organization

establishment of spindle localization [inference]

establishment of meiotic spindle localization

actin cytoskeleton organization

actomyosin structure organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

uropod organization

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane repair

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

cell-cell fusion [inference]

syncytium formation by cell-cell fusion [inference]

myoblast fusion

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

calcium-ion regulated exocytosis [inference]

cortical granule exocytosis

reproductive process [inference]

meiotic cell cycle process [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal gross anatomical part developmental process [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

cellular developmental process [inference]

cell differentiation

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

platelet formation

endodermal cell differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

protein transport

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis

calcium-ion regulated exocytosis [inference]

cortical granule exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

calcium-ion regulated exocytosis [inference]

cortical granule exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

calcium-ion regulated exocytosis [inference]

cortical granule exocytosis

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

vacuolar localization [inference]

lysosome localization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of actin filament severing

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of actin filament-based process

regulation of actin filament severing [inference]

negative regulation of actin filament severing

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

negative regulation of cellular process [inference]

negative regulation of actin filament severing

regulation of cellular component organization [inference]

regulation of plasma membrane organization [inference]

regulation of plasma membrane repair

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 48 in total

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GO Term	Evidence Code	PMID
stress fiber	IDA
stress fiber	IEA
ruffle	IDA
immunological synapse	IDA
immunological synapse	IEA

GO Hierarchy

cellular component

protein-containing complex

myosin complex

myosin II complex

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical structure [inference]

immunological synapse

cytoplasm

cell cortex

membrane

plasma membrane

plasma membrane region [inference]

cleavage furrow

cell junction [inference]

synapse [inference]

neuromuscular junction

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

cell leading edge

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

spindle

cytoskeleton

nuclear body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

cortical granule

intracellular membraneless organelle [inference]

spindle

cytoskeleton

nuclear body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

contractile ring [inference]

actomyosin contractile ring

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber

myosin filament

myosin II filament

Displaying entries **6 - 10** of 23 in total

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GO Term	Evidence Code	PMID
cytoskeletal motor activity	IEA
actin binding	IDA
integrin binding	IDA
protein binding	IPI
calmodulin binding

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

polypeptide conformation or assembly isomerase activity [inference]

microfilament motor activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

signaling receptor binding [inference]

integrin binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

protein domain specific binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

exogenous protein binding [inference]

virus receptor activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:1588	thrombocytopenia	Alliance of Genome Resources
DOID:0060651	MYH-9 related disease	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:0050567	orofacial cleft	Alliance of Genome Resources
DOID:0110032	Alport syndrome 3A	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:0110548	autosomal dominant nonsyndromic deafness 17	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	17886	MGI:107717

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements