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myosin heavy chain 11

Summary

Gene Symbol

MYH11

Organism

Homo sapiens (human)

External Links

NCBI Gene

4629

PubChem

4629

Alliance of Genome Resources

HGNC:7569

Annotation

Keyword

ATP-binding
Actin-binding
Alternative splicing
Aortic aneurysm
Calmodulin-binding
Chromosomal rearrangement
Coiled coil
Disease variant
Methylation
Myosin
Phosphoprotein
Proto-oncogene
Reference proteome
Thick filament

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35749	Myosin heavy chain 11 Myosin heavy chain, smooth muscle isoform SMMHC
A0A024QZJ4	Myosin heavy chain 11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
smooth muscle contraction	ISS
skeletal muscle myosin thick filament assembly	ISS
actomyosin structure organization	IBA
elastic fiber assembly	IMP	16444274
cardiac muscle cell development	IMP	16444274

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization

myosin filament organization [inference]

myosin filament assembly [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization

myosin filament organization [inference]

myosin filament assembly [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

protein-containing complex assembly [inference]

myosin filament assembly [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

myosin filament assembly [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

myosin filament organization [inference]

myosin filament assembly [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

elastic fiber assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

striated muscle myosin thick filament assembly [inference]

skeletal muscle myosin thick filament assembly

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS
muscle myosin complex	TAS	7684189
myosin II complex	IBA
myosin filament	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

myosin II complex

muscle myosin complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
microfilament motor activity	IBA
protein binding	IPI	19328794
calmodulin binding	IEA
ATP binding	IEA
structural constituent of muscle	IMP	16444274

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 7** entries
InterPro
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin S1 fragment, N-terminal
Myosin head, motor domain
Myosin tail
Myosin, N-terminal, SH3-like
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060610	megacystis-microcolon-intestinal hypoperistalsis syndrome	Alliance of Genome Resources
DOID:13832	patent ductus arteriosus	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	4619	SGD:S000001065
Saccharomyces cerevisiae S288C	4625	SGD:S000001065
Saccharomyces cerevisiae S288C	4627	SGD:S000001065
Saccharomyces cerevisiae S288C	4628	SGD:S000001065
Xenopus tropicalis	4629	Xenbase:XB-GENE-6459772
Saccharomyces cerevisiae S288C	8735	SGD:S000001065
Saccharomyces cerevisiae S288C	17879	SGD:S000001065
Mus musculus	17880		MOUSE17540
Saccharomyces cerevisiae S288C	17882	SGD:S000001065
Saccharomyces cerevisiae S288C	17883	SGD:S000001065

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements