GlyCosmos Portal

Submissions

paraoxonase 3

Summary

Gene Symbol

PON3

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 463548
PubChem: 463548

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6D2Y4U5
A0A2I3SMF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to toxic substance	IEA	30032202
establishment of localization in cell
carboxylic acid catabolic process
renal sodium ion transport
negative regulation of superoxide anion generation

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding
arylesterase activity	IEA	22301074 30032202
acyl-L-homoserine-lactone lactonohydrolase activity
protein homodimerization activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

serum paraoxonase/lactonase 3

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying entries **1 - 10** of 11 in total

1

2

Next ›

Last »
Gene Ontology
acyl-L-homoserine-lactone lactonohydrolase activity
aromatic compound catabolic process
arylesterase activity
carboxylic acid catabolic process
establishment of localization in cell
hydrolase activity
metal ion binding
negative regulation of superoxide anion generation
protein homodimerization activity
renal sodium ion transport

Displaying **all 3** entries
InterPro
Arylesterase
Paraoxonase2
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **1 - 10** of 55 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	5446	9606_0:001507	HUMAN89984
Mus musculus	269823		MOUSE51052
Rattus norvegicus	312086		RATNO30118
Bos taurus	510953		BOVIN27641
Macaca mulatta	699236		MACMU30779
Sus scrofa	733674		PIGXX36106
Equus caballus	100051959		HORSE32860
Ovis aries	100337686		SHEEP15304
Pongo abelii	100436262	9601_0:00215f	PONAB32953
Ailuropoda melanoleuca	100467660		AILME13080