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paraoxonase 3

Summary

Gene Symbol

PON3

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 463548
PubChem: 463548

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6D2Y4U5
A0A2I3SMF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to toxic substance	IEA	30032202
establishment of localization in cell
carboxylic acid catabolic process
renal sodium ion transport
negative regulation of superoxide anion generation

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding
arylesterase activity	IEA	22301074 30032202
acyl-L-homoserine-lactone lactonohydrolase activity
protein homodimerization activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

serum paraoxonase/lactonase 3

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying entry **11 - 11** of 11 in total

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Gene Ontology
response to toxic substance

Displaying **all 3** entries
InterPro
Arylesterase
Paraoxonase2
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **41 - 50** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Cercocebus atys	105592194	CERAT30821
Aotus nancymaae	105716199	AOTNA04270
Propithecus coquereli	105813129	PROCO13983
Dipodomys ordii	106000573	DIPOR21939
Equus asinus asinus	106838927	EQUAS02235
Rhinopithecus bieti	108513530	RHIBE16073
Phascolarctos cinereus	110217570	PHACI14303
Vulpes vulpes	112923904	VULVU17419
Bos indicus x Bos taurus	113891717	BOBOX16115
Bos indicus x Bos taurus	113891719	BOBOX16115