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myosin light chain kinase

Summary

Gene Symbol

MYLK

Organism

Homo sapiens (human)

External Links

NCBI Gene

4638

PubChem

4638

Alliance of Genome Resources

HGNC:7590

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Actin-binding
Alternative promoter usage
Alternative splicing
Aortic aneurysm
Calcium
Calmodulin-binding
Cell projection
Cytoskeleton
Direct protein sequencing
Disease variant
Disulfide bond
Immunoglobulin domain
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Serine/threonine-protein kinase

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q15746	Kinase-related protein Telokin
Q05B97
Q05B98
A0A8I5KTQ1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein phosphorylation	TAS	8575746
smooth muscle contraction	ISS
tonic smooth muscle contraction	ISS
tonic smooth muscle contraction	IBA
positive regulation of cell migration	IDA	19826488

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

bleb assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

bleb assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

bleb assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

tonic smooth muscle contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

aorta smooth muscle tissue morphogenesis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hypotonic response [inference]

cellular hypotonic response

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response [inference]

cellular hypotonic response

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular hypotonic response

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

positive regulation of wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
stress fiber	IDA	15020676
stress fiber	IBA
cytoplasm	IDA	20053363
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

cell junction [inference]

synapse

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
myosin light chain kinase activity	IDA	16284075
myosin light chain kinase activity	IBA
protein binding	IPI	17474147 25416956 32296183 35537812
calmodulin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

myosin light chain kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

myosin light chain kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

myosin light chain kinase activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

scaffold protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin light chain kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060610	megacystis-microcolon-intestinal hypoperistalsis syndrome	Alliance of Genome Resources
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4638	Xenbase:XB-GENE-923293
Xenopus tropicalis	36002	Xenbase:XB-GENE-923293
Mus musculus	107589		MOUSE19447
Rattus norvegicus	288057		RATNO03745
Sus scrofa	396848		PIGXX05529
Ovis aries	443334		SHEEP01449
Canis lupus familiaris	488012		CANLF13369
Felis catus	494213		FELCA22817
Macaca mulatta	715422		MACMU30470
Xenopus tropicalis	855336	Xenbase:XB-GENE-923293