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myosin IA

Summary

Gene Symbol

MYO1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

4640

PubChem

4640

Alliance of Genome Resources

HGNC:7595

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Myosin
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UBC5	Brush border myosin I Myosin I heavy chain
B2R643	Brush border myosin I Myosin I heavy chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IBA IMP	12736868
endocytosis	IBA
vesicle localization	IMP	8692943
microvillus assembly	IEA
actin filament-based movement	IBA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin filament-based movement

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

plasma membrane bounded cell projection organization [inference]

microvillus organization [inference]

microvillus assembly

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

organelle localization [inference]

vesicle localization

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane raft	IEA
myosin complex	IEA
lateral plasma membrane	IDA	9858156
microvillus	IBA IDA	9858156
apical plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

lateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

cluster of actin-based cell projections [inference]

brush border

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
actin filament binding	IBA
calmodulin binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 3** entries
InterPro
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 62 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Taeniopygia guttata	100222131			TAEGU16253
Oryctolagus cuniculus	100337769			RABIT14500
Callithrix jacchus	100389198			CALJA44693
Pongo abelii	100433686	9601_0:0032ca		PONAB05867
Ailuropoda melanoleuca	100475948			AILME16088
Anolis carolinensis	100555455			ANOCA02543
Loxodonta africana	100659785			LOXAF19588
Cavia porcellus	100727427			CAVPO05759
Sus scrofa	100739662			PIGXX25650
Cricetulus griseus	100752754			CRIGR16805

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024