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myosin VI

Summary

Gene Symbol

MYO6

Organism

Homo sapiens (human)

External Links

NCBI Gene

4646

PubChem

4646

Alliance of Genome Resources

HGNC:7605

Annotation

Keyword

3D-structure
ATP-binding
Actin-binding
Alternative splicing
Calmodulin-binding
Cardiomyopathy
Cell membrane
Cell projection
Coated pit
Cytoplasm
Cytoplasmic vesicle
Disease variant
Endocytosis
Endosome
Golgi apparatus
Hearing
Myosin
Non-syndromic deafness
Nucleus
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UM54	Unconventional myosin-6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	ISS
actin filament-based movement	IBA ISS NAS	10519557
inner ear auditory receptor cell differentiation	IBA
actin filament organization	IBA
regulation of secretion	IMP	15837803

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin filament-based movement

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

inner ear morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

response to chemical [inference]

response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

Displaying entries **21 - 25** of 28 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
autophagosome	IEA
perinuclear region of cytoplasm	IDA ISS	9852149
cytoplasm	IBA IDA ISS	16507995 16949370 9852149
unconventional myosin complex	TAS	9259267

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

unconventional myosin complex

filamentous actin

cellular anatomical entity [inference]

nucleoplasm

cytoplasm

cell cortex

cytosol

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

nuclear membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

clathrin-coated pit

cell projection membrane [inference]

ruffle membrane

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11447109 11967127 15247260 15837803 16169070 16908842 22323290 23023224 28514442 29467281 33961781 35271311
microfilament motor activity	IBA
actin binding	TAS	10519557
actin filament binding	IBA IDA ISS	9852149
calmodulin binding	ISS TAS	12857860

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

minus-end directed microfilament motor activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP-dependent activity [inference]

microfilament motor activity

minus-end directed microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heavy chain

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
actin filament organization
cytoskeletal motor activity
nucleotide binding
vesicle transport along actin filament

Displaying **all 3** entries
InterPro
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0110495	autosomal recessive nonsyndromic deafness 37	Alliance of Genome Resources
DOID:0110552	autosomal dominant nonsyndromic deafness 22	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Serinus canaria	103822577		SERCA02667
Rhinopithecus roxellana	104669293		RHIRO10490
Macaca nemestrina	105479431		MACNE16994
Mandrillus leucophaeus	105528878		MANLE31081
Cercocebus atys	105588090		CERAT26768
Aotus nancymaae	105730500		AOTNA08722
Dipodomys ordii	105999162		DIPOR20003
Rhinopithecus bieti	108535235		RHIBE31292
Xenopus laevis	108717993	Xenbase:XB-GENE-17344543
Crocodylus porosus	109312117		CROPO09952