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prostaglandin-endoperoxide synthase 1

Summary

Gene Symbol

PTGS1

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 464713
KEGG Gene ID: ptr:464713
PubChem: 464713

Annotation

Keyword

Dioxygenase
EGF-like domain
Heme
Microsome
Peroxidase
Prostaglandin biosynthesis
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
K7C9Z9	Cyclooxygenase-1 Prostaglandin H2 synthase 1 Prostaglandin-endoperoxide synthase 1
A0A663D5C7	Cyclooxygenase-1 Prostaglandin H2 synthase 1 Prostaglandin-endoperoxide synthase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
response to oxidative stress	IEA	22301074
cyclooxygenase pathway	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
neuron projection	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peroxidase activity	IEA	22301074
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	30032202
heme binding	IEA	22301074
prostaglandin-endoperoxide synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

prostaglandin-endoperoxide synthase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00509

Name

prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]

References

Rhea

RHEA:23728

O₂ + AH₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

A + H₂O + prostaglandin H₂

Enzyme

1.14.99.1

PMID

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Orthologous MAtrix
Callorhinchus milii	103184666	CALMI30428
Lepisosteus oculatus	102685083	LEPOC08476
Astyanax mexicanus	103025268	ASTMX03328
Ictalurus punctatus	108255976	ICTPU17435
Electrophorus electricus	113587050	ELEEL38324
Salmo trutta	115164731	SALTR60538
Salmo trutta	115199905	SALTR21666
Gadus morhua	115548479	GADMO56955
Xiphophorus maculatus	102224819	XIPMA33545
Chrysemys picta bellii	101945575	CHRPI11012