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Guidelines

MIRAGE

myosin VIIA

Summary

Gene Symbol

MYO7A

Organism

Homo sapiens (human)

External Links

NCBI Gene

4647

PubChem

4647

Alliance of Genome Resources

HGNC:7606

Annotation

Keyword

3D-structure
ATP-binding
Actin-binding
Alternative splicing
Calmodulin-binding
Cytoskeleton
Disease variant
Hearing
Leber congenital amaurosis
Myosin
Non-syndromic deafness
Phosphoprotein
Reference proteome
Repeat
Retinitis pigmentosa
SH3 domain
Synapse
Usher syndrome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13402

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
phagolysosome assembly	IEA
intracellular protein transport	IEA
endocytosis	IBA
actin filament organization	IBA
lysosome organization	IDA	16001398

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin filament-based movement

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

phagolysosome assembly

vesicle organization [inference]

phagolysosome assembly

organelle assembly [inference]

phagolysosome assembly

cellular component assembly [inference]

organelle assembly [inference]

phagolysosome assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization [inference]

auditory receptor cell stereocilium organization

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

equilibrioception

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

animal organ development [inference]

sensory organ development

cochlea development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

intracellular transport [inference]

intracellular protein transport

pigment granule transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

pigment granule transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

pigment granule transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

pigment granule transport

pigment granule localization [inference]

pigment granule transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

pigment granule transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
apical plasma membrane	IEA
myosin VII complex	IEA
photoreceptor connecting cilium	IEA
stereocilium	ISS
melanosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

unconventional myosin complex [inference]

myosin VII complex

cellular anatomical entity [inference]

cell cortex

cytosol

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

synapse

ciliary transition zone [inference]

photoreceptor connecting cilium

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

stereocilium base

stereocilia tip-link density [inference]

upper tip-link density

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
protein domain specific binding	IEA
spectrin binding	IDA	23704327
identical protein binding	IEA
ADP binding	IEA
actin filament binding	IDA	21687988

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

spectrin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

protein-containing complex binding [inference]

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
actin binding
cytoskeletal motor activity
nucleotide binding

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InterPro
Band 4.1 domain
Class VII myosin, motor domain
FERM central domain
FERM domain
FERM superfamily, second domain
FERM/acyl-CoA-binding protein superfamily
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
MyTH4 domain superfamily
MyTH4 domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050439	Usher syndrome	Alliance of Genome Resources
DOID:0110477	autosomal recessive nonsyndromic deafness 2	Alliance of Genome Resources
DOID:0110543	autosomal dominant nonsyndromic deafness 11	Alliance of Genome Resources
DOID:0110826	Usher syndrome type 1	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:14791	Leber congenital amaurosis	Alliance of Genome Resources
DOID:9649	congenital nystagmus	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4647	Xenbase:XB-GENE-494060
Caenorhabditis elegans	4648	WB:WBGene00002039
Mus musculus	17921		MOUSE54674
Caenorhabditis elegans	17922	WB:WBGene00002039
Rattus norvegicus	266714		RATNO15521
Sus scrofa	397373		PIGXX35055
Canis lupus familiaris	485174		CANLF08243
Macaca mulatta	699411		MACMU11296
Equus caballus	100063344		HORSE39759
Ornithorhynchus anatinus	100084198		ORNAN13257

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Last updated: December 8, 2025