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nibrin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4683

PubChem

4683

Alliance of Genome Resources

HGNC:7652

Annotation

Keyword

3D-structure
Cell cycle
DNA repair
Direct protein sequencing
Disease variant
Host-virus interaction
Isopeptide bond
Meiosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Telomere
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0C4DG07
O60934	Cell cycle regulatory protein p95 Nijmegen breakage syndrome protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
DNA damage checkpoint signaling	IDA	12529385
telomere maintenance	IMP	11448772
double-strand break repair via homologous recombination	IDA	22464731 23115235 27814491 27889449 28867292 30787182 30952868 38961290
double-strand break repair via homologous recombination	IBA
DNA double-strand break processing	NAS	26512707

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cell cycle [inference]

meiotic cell cycle

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

reproductive process [inference]

meiotic cell cycle

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

growth [inference]

developmental growth [inference]

blastocyst growth

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of kinase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of cell cycle

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	ISS
chromosome, telomeric region	IDA	10888888 28216226
chromosome, telomeric region	HDA	19135898
nucleus	NAS	18171670
nucleus	IDA	10888888

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

nuclear inclusion body

nuclear body [inference]

PML body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

site of DNA damage [inference]

site of double-strand break

chromosomal region

chromosome, telomeric region

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GO Term	Evidence Code	PMID
damaged DNA binding	IC	9590180
damaged DNA binding	IBA
protein binding	IPI	12419185 12470659 12607005 15916964 16377563 17500065 17612497 18001824 18001825 18583988 18678890 19609304 19683501 19759395 19804756 20224574 21108945 22078559 22157895 22565321 24534091 24651726 24981860 25064736 25558984 25895060 26869104 27568553 29656893 9590181
histone binding	IPI	19338747
protein serine/threonine kinase activator activity	IDA	16622404

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding

histone binding

modification-dependent protein binding [inference]

phosphorylation-dependent protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nibrin

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
DNA duplex unwinding
cell cycle
damaged DNA binding
double-strand break repair

Displaying **all 8** entries
InterPro
BRCT domain superfamily
BRCT domain
Forkhead-associated (FHA) domain
Nibrin, C-terminal
Nibrin, second BRCT domain superfamily
Nibrin, second BRCT domain
Nibrin-related
SMAD/FHA domain superfamily

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:12449	aplastic anemia	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:7400	Nijmegen breakage syndrome	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4683	Xenbase:XB-GENE-943036
Mus musculus	27354		MOUSE42701
Rattus norvegicus	85482		RATNO34931
Pan troglodytes	464278		PANTR42910
Bos taurus	522943		BOVIN06215
Canis lupus familiaris	611315		CANLF11782
Equus caballus	100050939		HORSE42316
Ornithorhynchus anatinus	100091643		ORNAN19558
Pongo abelii	100172091		PONAB34420
Taeniopygia guttata	100223052		TAEGU16883

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements