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glutamate decarboxylase 1

Summary

Gene Symbol

GAD1

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 468557
KEGG Gene ID: ptr:468557
PubChem: 468557

Annotation

Keyword

Decarboxylase
Neurotransmitter biosynthesis
Phosphoprotein
Pyridoxal phosphate
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2J8PQQ8
Q5IS68	67 kDa glutamic acid decarboxylase Glutamate decarboxylase 67 kDa isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
gamma-aminobutyric acid biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
presynaptic active zone	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glutamate decarboxylase activity	IEA	30032202
pyridoxal phosphate binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

glutamate decarboxylase activity

binding [inference]

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01580

Name

glutamate decarboxylase [EC:4.1.1.15]

References

Rhea

H⁺ + L-glutamate

CO₂ + 4-aminobutanoate

Enzyme

4.1.1.15

PMID

Ortholog

Displaying entries **81 - 85** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cyprinus carpio carpio	109054551		CYPCA50189
Cyprinus carpio carpio	109085111		CYPCA45879
Nannospalax galili	103751726		NANGA02635
Corvus moneduloides	116446341		CORMO24502
Strigops habroptila	115609088		STRHB03581

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024