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prostaglandin-endoperoxide synthase 2

Summary

Gene Symbol

PTGS2

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 469616
KEGG Gene ID: ptr:469616
PubChem: 469616

Annotation

Keyword

Dioxygenase
EGF-like domain
Heme
Microsome
Peroxidase
Prostaglandin biosynthesis
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
H2Q0S9	Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2
A0A6D2XHJ5	Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
response to oxidative stress	IEA	22301074
cyclooxygenase pathway	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
neuron projection	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peroxidase activity	IEA	22301074
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	30032202
heme binding	IEA	22301074
prostaglandin-endoperoxide synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

prostaglandin-endoperoxide synthase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K11987

Name

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

References

Rhea

RHEA:23728

O₂ + AH₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

A + H₂O + prostaglandin H₂

Enzyme

1.14.99.1

PMID

Ortholog

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Species	Gene ID	Orthologous MAtrix
Oryzias latipes	100359365	ORYLA13221
Sparus aurata	115592011	SPAAU68949
Chrysemys picta bellii	101941281	CHRPI29278
Crocodylus porosus	109307218	CROPO13686
Pseudonaja textilis	113438049	PSETE09593
Meleagris gallopavo	100550092	MELGA02048
Serinus canaria	103814802	SERCA08063
Ornithorhynchus anatinus	100086096	ORNAN08377
Sarcophilus harrisii	100926756	SARHA12611
Callithrix jacchus	100407639	CALJA16242