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ATM serine/threonine kinase
Summary
- Gene Symbol
-
- ATM
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Cell cycle
- Cytoplasmic vesicle
- Cytoskeleton
- DNA damage
- DNA-binding
- Disease variant
- Neurodegeneration
- Nucleus
- Peroxisome
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Tumor suppressor
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13315 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| male meiotic nuclear division | ||
| female meiotic nuclear division | ||
| signal transduction | ||
| brain development | ||
| heart development |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
signal transduction
cellular metabolic process [inference]
cellular response to stimulus [inference]
reproductive process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular component organization [inference]
regulation of cell cycle
regulation of mitotic cell cycle [inference]
regulation of cell cycle process [inference]
negative regulation of cell cycle process [inference]
regulation of chromosome segregation [inference]
regulation of cell cycle phase transition [inference]
negative regulation of cell cycle [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromosome, telomeric region | ||
| nucleus | ||
| nucleus | ||
| nucleoplasm | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| 3-phosphoinositide-dependent protein kinase activity |
GO Hierarchy
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
- 3-phosphoinositide-dependent protein kinase activity
- DNA-dependent protein kinase activity
- AMP-activated protein kinase activity
- eukaryotic translation initiation factor 2alpha kinase activity
- ribosomal protein S6 kinase activity
- histone H3S10 kinase activity
- histone H3T11 kinase activity
- histone H3T6 kinase activity
- histone H2AXS139 kinase activity
- histone H3S28 kinase activity
- histone H4S1 kinase activity
- histone H2AS1 kinase activity
- histone H2BS14 kinase activity
- histone H3T3 kinase activity
- histone H2AS121 kinase activity
- Rho-dependent protein serine/threonine kinase activity
- histone H2BS36 kinase activity
- histone H3S57 kinase activity
- histone H3T45 kinase activity
- histone H2AT120 kinase activity
- protein serine kinase activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity [inference]
protein serine/threonine kinase activity
histone kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity [inference]
protein serine/threonine kinase activity
histone kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity [inference]
protein serine/threonine kinase activity
histone kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050671 | female breast cancer | |
| DOID:12704 | ataxia telangiectasia | |
| DOID:1380 | endometrial cancer | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:3907 | lung squamous cell carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3969 | papillary thyroid carcinoma | |
| DOID:5409 | lung small cell carcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100402387 | CALJA05498 | ||
| 100427400 | MACMU10242 | ||
| 100451505 | PONAB03555 | ||
| 100480638 | AILME02541 | ||
| 100597791 | NOMLE10277 | ||
| 100663914 | LOXAF08934 | ||
| 100694314 | ORENI17477 | ||
| 100717983 | CAVPO23440 | ||
| 100925167 | SARHA15950 | ||
| 100947578 | OTOGA07854 |
