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transmembrane 7 superfamily member 2

Summary

Gene Symbol

TM7SF2

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 476027
KEGG Gene ID: cfa:476027
PubChem: 476027

Annotation

Keyword

Cholesterol biosynthesis
Endoplasmic reticulum
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8I3Q0D3	3-beta-hydroxysterol Delta (14)-reductase C-14 sterol reductase Sterol C14-reductase Transmembrane 7 superfamily member 2
A0A8C0Z2V7	3-beta-hydroxysterol Delta (14)-reductase C-14 sterol reductase Sterol C14-reductase Transmembrane 7 superfamily member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
sterol biosynthetic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

sterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

sterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

sterol metabolic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nuclear inner membrane	IEA	30032202
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane [inference]

nuclear inner membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
oxidoreductase activity
steroid biosynthetic process
steroid metabolic process
sterol biosynthetic process

Displaying **all 2** entries
InterPro
Sterol biosynthesis ERG24/DHCR-like
Sterol reductase, conserved site

KEGG BRITE Database

Orthology

K00222

Name

Delta14-sterol reductase [EC:1.3.1.70]

References

Rhea

RHEA:18561

4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol + NADP⁺

H⁺ + 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol + NADPH

Enzyme

1.3.1.70

PMID

Ortholog

Displaying entries **91 - 100** of **103** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Neogale vison	122913093	452646_0:0028b4
Leopardus geoffroyi	123601934	46844_0:0015d7
Ursus americanus	123778309	9643_0:00410d	URSAM06386
Mirounga angustirostris	123856981	9716_0:002ad9
Meles meles	123949949	9662_0:0023d5
Lynx rufus	124504863	61384_0:0049ab
Lutra lutra	125078164	9657_0:003247
Prionailurus viverrinus	125176094	61388_0:002fe9
Panthera uncia	125930942	29064_0:000aff
Nyctereutes procyonoides	129500676	34880_0:0008bf

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements