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cytochrome P450 family 17 subfamily A member 1

Summary

Gene Symbol

CYP17A1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 477807
KEGG Gene ID: cfa:477807
PubChem: 477807

Annotation

Keyword

Endoplasmic reticulum
Heme
Membrane
Monooxygenase
Reference proteome
Signal
Steroidogenesis

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8I3PR85	17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Steroid 17-alpha-monooxygenase
A0A8C0PJZ0	17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Steroid 17-alpha-monooxygenase
A0A8C0TRG3	17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Steroid 17-alpha-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hormone biosynthetic process	IEA	30032202
progesterone metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

olefinic compound metabolic process [inference]

progesterone metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
steroid 17-alpha-monooxygenase activity	IEA	30032202
iron ion binding	IEA	22301074
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

steroid 17-alpha-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

steroid 17-alpha-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K00512

Name

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

References

Rhea

RHEA:50236

O₂ + pregnenolone

H₂O + H⁺ + 17α-hydroxypregnenolone

Enzyme

1.14.14.19

PMID

9452426

RHEA:50244

O₂ + 17α-hydroxypregnenolone

H₂O + H⁺ + 3β-hydroxyandrost-5-en-17-one + acetate

Enzyme

PMID

RHEA:65760

O₂ + a C₂₁-steroid

a 17α-hydroxy-C₂₁-steroid + H₂O + H⁺

Enzyme

1.14.14.19

PMID

RHEA:14753

O₂ + 17α-hydroxyprogesterone

H₂O + H⁺ + androst-4-ene-3,17-dione + acetate

Enzyme

PMID

RHEA:46308

O₂ + progesterone

H₂O + H⁺ + 17α-hydroxyprogesterone

Enzyme

1.14.14.19

PMID

Ortholog

Displaying entries **41 - 50** of **125** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chinchilla lanigera	102011010		CHILA18877
Capra hircus	102182376		CAPHI17779
Capra hircus	102182663		CAPHI17778
Myotis lucifugus	102417518		MYOLU09618
Pelodiscus sinensis	102457785		PELSI08765
Leptonychotes weddellii	102745940	9713_0:000cfe
Panthera tigris	102966057	9694_0:0035ba
Astyanax mexicanus	103036160		ASTMX06597
Callorhinchus milii	103177103		CALMI12168
Chlorocebus sabaeus	103216445		CHLSB18075

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External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements