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Guidelines

MIRAGE

isocitrate dehydrogenase (NADP(+)) 1

Summary

Gene Symbol

IDH1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 478889
KEGG Gene ID: cfa:478889
PubChem: 478889

Annotation

Keyword

Glyoxylate bypass
Magnesium
Manganese
Metal-binding
NADP
Oxidoreductase
Reference proteome
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8C0MYC5
F1PZA1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
isocitrate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202
peroxisome	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
magnesium ion binding	IEA	22301074
isocitrate dehydrogenase (NADP+) activity	IEA	22301074 30032202
NAD binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NADP+) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isocitrate dehydrogenase (NADP)

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 9** entries
Gene Ontology
NADP metabolic process
glyoxylate cycle
isocitrate dehydrogenase (NADP+) activity
isocitrate metabolic process
magnesium ion binding
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NADP-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

KEGG BRITE Database

Orthology

K00031

Name

isocitrate dehydrogenase [EC:1.1.1.42]

References

Rhea

D-threo-isocitrate + NADP⁺

CO₂ + 2-oxoglutarate + NADPH

Enzyme

1.1.1.42

PMID

Ortholog

Displaying entries **41 - 50** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Erinaceus europaeus	103110967		ERIEU04355
Callorhinchus milii	103182930		CALMI26171
Chlorocebus sabaeus	103217738		CHLSB01570
Carlito syrichta	103264693		CARSF18878
Ursus maritimus	103659809		URSMA01528
Nannospalax galili	103744452		NANGA01155
Serinus canaria	103814474		SERCA06995
Rhinopithecus roxellana	104672972		RHIRO37826
Pteropus vampyrus	105298394		PTEVA10166
Macaca nemestrina	105467989		MACNE08563

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025