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tonsoku like, DNA repair protein

Summary

Gene Symbol

TONSL

Organism

Homo sapiens (human)

External Links

NCBI Gene

4796

PubChem

4796

Alliance of Genome Resources

HGNC:7801

JoGo

TONSL

TogoVar

TONSL

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Chromatin regulator
Chromosome
Cytoplasm
DNA repair
Disease variant
Dwarfism
Leucine-rich repeat
Methylation
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
TPR repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96HA7	Inhibitor of kappa B-related protein NF-kappa-B inhibitor-like protein 2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	IDA	27338793 27797818
double-strand break repair via homologous recombination	IMP	21055983 21055984 21055985 30773278
double-strand break repair via homologous recombination	IBA
chromatin organization	IEA
replication fork processing	IDA	27338793 29478807

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
DNA replication factor A complex	IDA	21055983
cytoplasm	IEA
nuclear body	IDA
FACT complex	IDA	21055983

GO Hierarchy

cellular component

protein-containing complex [inference]

MCM complex

nuclear protein-containing complex [inference]

DNA replication factor A complex

transcription elongation factor complex [inference]

FACT complex

cellular anatomical entity [inference]

nucleoplasm

replication fork [inference]

nuclear replication fork

site of DNA damage [inference]

site of double-strand break

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21055983 21055984 21055985 21113133 27797818
histone binding	IDA	21055983 21055984
histone reader activity	IDA	26527279 27338793 29478807

GO Hierarchy

molecular function

binding [inference]

protein binding

histone binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity [inference]

histone reader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tonsoku-like protein

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Leucine-rich repeat domain superfamily
Leucine-rich repeat
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily