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MIRAGE
notch receptor 1
Summary
- Gene Symbol
-
- NOTCH1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ANK repeat
- Activator
- Angiogenesis
- Calcium
- Cell membrane
- Developmental protein
- Differentiation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Hydroxylation
- Isopeptide bond
- Metal-binding
- Notch signaling pathway
- Nucleus
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transcription regulation
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P46531 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of endothelial cell chemotaxis |
GO Hierarchy
- regulation of somitogenesis
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
cellular developmental process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of growth [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
regulation of epithelial cell differentiation [inference]
negative regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of glial cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
regulation of epidermis development [inference]
negative regulation of developmental process [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
regulation of epithelial cell differentiation [inference]
negative regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of glial cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of epithelial cell migration [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| acrosomal vesicle | ||
| MAML1-RBP-Jkappa- ICN1 complex | ||
| extracellular region | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cis-regulatory region sequence-specific DNA binding | ||
| DNA-binding transcription activator activity, RNA polymerase II-specific | ||
| transcription coactivator activity | ||
| transcription coactivator activity | ||
| enzyme inhibitor activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- N
- Functional Category
-
- G: Carbohydrate transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| InterPro |
|---|
| EGF-like calcium-binding domain |
| EGF-like calcium-binding, conserved site |
| EGF-like domain |
| EGF-type aspartate/asparagine hydroxylation site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050523 | adult T-cell leukemia/lymphoma | |
| DOID:0060227 | Adams-Oliver syndrome | |
| DOID:0080333 | aortic valve disease 1 | |
| DOID:1682 | congenital heart disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 4851 | Xenbase:XB-GENE-479318 | ||
| 4853 | FB:FBgn0004647 | ||
| 4854 | FB:FBgn0004647 | ||
| 4855 | WB:WBGene00001609 | ||
| 18128 | Xenbase:XB-GENE-479318 | MOUSE35614 | |
| 18129 | FB:FBgn0004647 | ||
| 18131 | FB:FBgn0004647 | ||
| 25496 | Xenbase:XB-GENE-479318 | RATNO27024 | |
| 30718 | Xenbase:XB-GENE-479318 | ||
| 31293 | Xenbase:XB-GENE-479318 |
