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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
notch receptor 2
Summary
- Gene Symbol
-
- NOTCH2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ANK repeat
- Activator
- Cell membrane
- Cytoplasm
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Notch signaling pathway
- Nucleus
- Osteoporosis
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transcription regulation
- Transmembrane helix
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of osteoclast differentiation | ||
| myeloid dendritic cell differentiation | ||
| atrial septum morphogenesis | ||
| wound healing | ||
| ciliary body morphogenesis |
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| receptor complex | ||
| endoplasmic reticulum membrane | ||
| plasma membrane | ||
| extracellular region |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| NF-kappaB binding | ||
| enzyme binding | ||
| signaling receptor activity | ||
| DNA-binding transcription activator activity, RNA polymerase II-specific |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Notch
- Functional Category
-
- G: Carbohydrate transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| InterPro |
|---|
| EGF-like calcium-binding domain |
| EGF-like calcium-binding, conserved site |
| EGF-like domain |
| EGF-type aspartate/asparagine hydroxylation site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10155 | intestinal cancer | |
| DOID:10591 | pre-eclampsia | |
| DOID:1319 | brain cancer | |
| DOID:1574 | alcohol use disorder | |
| DOID:162 | cancer | |
| DOID:2736 | Hajdu-Cheney syndrome | |
| DOID:299 | adenocarcinoma | |
| DOID:3620 | central nervous system cancer | |
| DOID:9245 | Alagille syndrome | |
| DOID:9256 | colorectal cancer |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18129 | MGI:97364 | MOUSE37730 | ||
| 29492 | RGD:3188 | RATNO23892 | ||
| 31293 | FB:FBgn0004647 | |||
| 58065 | ZFIN:ZDB-GENE-000329-4 | DANRE43017 | ||
| 176286 | WB:WBGene00001609 | |||
| 457173 | 9598_0:000749 | |||
| 513730 | BOVIN26129 | |||
| 713798 | MACMU22322 | |||
| 723806 | CIOIN11435 | |||
| 100013355 | MONDO14528 |
