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Guidelines

MIRAGE

natriuretic peptide receptor 3

Summary

Gene Symbol

NPR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4883

PubChem

4883

Alliance of Genome Resources

HGNC:7945

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Chloride
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P17342	Atrial natriuretic peptide clearance receptor Atrial natriuretic peptide receptor type C
A8K4A5
Q60I31

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
skeletal system development	ISS
angiogenesis	IEA
blood vessel remodeling	IEA
osteoclast proliferation	ISS
response to ischemia	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

osteoclast proliferation

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

system development [inference]

skeletal system development

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

regulation of osteoblast proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IC	1660465
protein-containing complex	IDA	16870210
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16870210
G protein-coupled peptide receptor activity	ISS
natriuretic peptide receptor activity	IDA	1660465
natriuretic peptide receptor activity	IBA
peptide hormone binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding

peptide hormone binding

hormone binding

peptide hormone binding

ion binding [inference]

anion binding [inference]

chloride ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atrial natriuretic peptide receptor

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
natriuretic peptide receptor activity
peptide hormone binding

Displaying **all 3** entries
InterPro
Adenylyl cyclase class-4/guanylyl cyclase
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mustela putorius furo	101670259		MUSPF19890
Chrysemys picta bellii	101952539		CHRPI02614
Ictidomys tridecemlineatus	101967571		ICTTR02888
Chinchilla lanigera	102024479		CHILA08087
Macaca fascicularis	102121278		MACFA35271
Capra hircus	102185687		CAPHI13227
Myotis lucifugus	102421374		MYOLU05861
Pelodiscus sinensis	102452975		PELSI14811
Astyanax mexicanus	103047079		ASTMX06934
Erinaceus europaeus	103120137		ERIEU12733

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Last updated: December 8, 2025