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G protein-coupled receptor 143

Summary

Gene Symbol

GPR143

Organism

Homo sapiens (human)

External Links

NCBI Gene

4935

PubChem

4935

Alliance of Genome Resources

HGNC:20145

Annotation

Keyword

Albinism
Cell membrane
Disease variant
G-protein coupled receptor
Glycoprotein
Lysosome
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51810	Ocular albinism type 1 protein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
eye pigment biosynthetic process	TAS	7647783
signal transduction	TAS	10471510
G protein-coupled receptor signaling pathway	IMP	18828673
G protein-coupled receptor signaling pathway	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	16524428

GO Hierarchy

biological process

metabolic process [inference]

pigment metabolic process [inference]

pigment metabolic process involved in pigmentation [inference]

pigment metabolic process involved in developmental pigmentation [inference]

eye pigment metabolic process [inference]

eye pigment biosynthetic process

pigment biosynthetic process [inference]

eye pigment biosynthetic process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

localization [inference]

establishment of localization [inference]

transport [inference]

pigment granule transport [inference]

melanosome transport

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

pigment granule localization [inference]

melanosome localization

melanosome transport

pigment granule transport [inference]

melanosome transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of melanosome transport

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of melanosome organization

regulation of melanosome transport

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytoplasm	TAS	10471510
lysosomal membrane	IDA	16621890
Golgi apparatus	IDA	19717472
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

pigment granule membrane [inference]

melanosome membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IDA	16524428
protein binding	IPI	16524428 19717472 27720922
dopamine binding	IDA	18828673
dopamine binding	IBA
L-DOPA receptor activity	IDA	18828673

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

cation binding [inference]

dopamine binding

modified amino acid binding [inference]

L-DOPA binding

organic cyclic compound binding [inference]

catecholamine binding [inference]

dopamine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

L-DOPA receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

L-DOPA receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor 143

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
L-DOPA binding
L-DOPA receptor activity
dopamine binding
melanosome organization
regulation of calcium-mediated signaling
tyrosine binding

Displaying 1 entry
InterPro
G-protein coupled receptor 143

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050633	ocular albinism 1	Alliance of Genome Resources
DOID:0111795	congenital nystagmus 6	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4935	Xenbase:XB-GENE-5848649
Mus musculus	18241	Xenbase:XB-GENE-5848649	MOUSE65186
Rattus norvegicus	302619		RATNO44185
Danio rerio	393795		DANRE45263
Pan troglodytes	465482		PANTR45457
Bos taurus	613505		BOVIN37494
Macaca mulatta	709148		MACMU47852
Monodelphis domestica	100032098		MONDO31834
Ornithorhynchus anatinus	100084484		ORNAN07161
Equus caballus	100147328		HORSE43828

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements