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exostosin glycosyltransferase 2

Summary

Gene Symbol

ext2

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

493780

KEGG Gene ID

dre:493780

PubChem

493780

Alliance of Genome Resources

ZFIN:ZDB-GENE-041124-3

Annotation

Keyword

Endoplasmic reticulum
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5U7A7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
skeletal system development	IMP	18654627
ossification	IMP	21294126 22253766
osteoblast differentiation	IMP	18654627
protein glycosylation	IEA
fibroblast growth factor receptor signaling pathway	IGI	10976049

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell motility [inference]

cell migration [inference]

neuromast primordium migration [inference]

posterior lateral line neuromast primordium migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis

appendage morphogenesis [inference]

fin morphogenesis [inference]

pectoral fin morphogenesis

embryonic pectoral fin morphogenesis

embryonic appendage morphogenesis [inference]

embryonic pectoral fin morphogenesis

tube morphogenesis [inference]

semicircular canal morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic pectoral fin morphogenesis

semicircular canal morphogenesis

anatomical structure development [inference]

animal organ development [inference]

hematopoietic or lymphoid organ development [inference]

thymus development

gland development [inference]

thymus development

cartilage development

system development [inference]

skeletal system development

appendage development [inference]

fin development [inference]

pectoral fin development

limb development [inference]

pectoral fin development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of axon extension

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	IEA
Golgi apparatus	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acetylglucosaminyltransferase activity	IBA
transferase activity	IEA
glycosyltransferase activity	IEA
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	ISS	15603738
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyltransferase activity [inference]

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyltransferase activity [inference]

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K02367

Name

glucuronyl/N-acetylglucosaminyl transferase EXT2 [EC:2.4.1.224 2.4.1.225]

References

9756849

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05935	2.4.1.225	G13581JW	G74553IH
R10138	2.4.1.225	G18844FT	G70244WB

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:206	hereditary multiple exostoses	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2132	Xenbase:XB-GENE-867542	HUMAN05530
Mus musculus	14043	Xenbase:XB-GENE-867542	MOUSE33620
Bos taurus	281151		BOVIN07457
Rattus norvegicus	311215	Xenbase:XB-GENE-867542	RATNO29138
Xenopus tropicalis	380140	Xenbase:XB-GENE-867542
Xenopus tropicalis	398750	Xenbase:XB-GENE-867542
Canis lupus familiaris	475989		CANLF05885
Xenopus tropicalis	493780	Xenbase:XB-GENE-867542
Xenopus tropicalis	3772101	Xenbase:XB-GENE-867542
Monodelphis domestica	100010947		MONDO27241

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External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements