GlyCosmos Portal

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GO Term	Evidence Code	PMID
magnesium ion binding	NAS	11017080
GTPase activity	TAS	11017080
GTPase activity	IDA	20185555 27667664 32228866 32245890 32379273 37612504 37612506
GTPase activity	IBA
protein binding	IPI	20436456 21081504 21364629 24282027 24344202 28746876 31046837

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidic acid binding

phosphatidylglycerol binding [inference]

cardiolipin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

phosphatidic acid binding

phosphatidylglycerol binding [inference]

cardiolipin binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

fusogenic activity [inference]

GTPase-dependent fusogenic activity

membrane bending activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dynamin

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 2** entries
Gene Ontology
GTP binding
microtubule binding

Displaying **all 7** entries
InterPro
Dynamin stalk domain
Dynamin, GTPase domain
Dynamin, N-terminal
Dynamin-type guanine nucleotide-binding (G) domain
Dynamin
GTPase effector domain
P-loop containing nucleoside triphosphate hydrolase

Human Protein Atlas

ENSG00000198836

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080336	mitochondrial DNA depletion syndrome 14	Alliance of Genome Resources
DOID:0111340	dominant optic atrophy plus syndrome	Alliance of Genome Resources
DOID:0111441	optic atrophy 1	Alliance of Genome Resources
DOID:0111580	Behr syndrome	Alliance of Genome Resources
DOID:5723	optic atrophy	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **114** in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000135	Hypogonadism
HP:0000407	Sensorineural hearing impairment
HP:0000408	Progressive sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000505	Visual impairment
HP:0000508	Ptosis
HP:0000518	Cataract
HP:0000529	Progressive visual loss

Displaying **all 6** entries
Disease ID	Disease Name
OMIM:616896	mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type)
ORPHA:1215	autosomal dominant optic atrophy plus syndrome
ORPHA:98673	autosomal dominant optic atrophy, classic form
OMIM:125250	optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
OMIM:165500	autosomal dominant optic atrophy, classic form
OMIM:210000	Behr syndrome

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4976	Xenbase:XB-GENE-989058
Mus musculus	74143		MOUSE19287
Rattus norvegicus	171116		RATNO04466
Pan troglodytes	471042		PANTR32957
Danio rerio	492332		DANRE38545
Bos taurus	524142		BOVIN14764
Macaca mulatta	698540		MACMU29607
Monodelphis domestica	100013661		MONDO32224
Equus caballus	100059993		HORSE14176
Pongo abelii	100172619		PONAB26960

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements