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izumo sperm-oocyte fusion 1

Summary

Gene Symbol

Izumo1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

499152

PubChem

499152

Alliance of Genome Resources

RGD:1565454

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Disulfide bond
Fertilization
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JB60
Q6AY06	Oocyte binding/fusion factor Sperm-specific protein izumo

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
syncytium formation by plasma membrane fusion	ISS
syncytium formation by plasma membrane fusion	ISO
single fertilization	ISO
binding of sperm to zona pellucida	ISO
binding of sperm to zona pellucida	IMP	35096839

GO Hierarchy

biological process

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion

cell adhesion [inference]

cell-cell adhesion [inference]

heterotypic cell-cell adhesion

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition

binding of sperm to zona pellucida

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion

reproductive process [inference]

fertilization [inference]

single fertilization

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

sperm-egg recognition

binding of sperm to zona pellucida

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISS
acrosomal vesicle	ISO
acrosomal membrane	ISS
acrosomal membrane	ISO
acrosomal membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-cell adhesion

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
signaling receptor binding	IBA
protein binding	IPI	37951137
identical protein binding	ISO
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor ligand activity

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

protein binding involved in heterotypic cell-cell adhesion

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

izumo sperm-egg fusion protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fusion of sperm to egg plasma membrane involved in single fertilization
protein binding involved in heterotypic cell-cell adhesion
signaling receptor binding
sperm-egg recognition