GlyCosmos Portal

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6AYT7	2-arachidonoylglycerol hydrolase ABHD12 Abhydrolase domain-containing protein 12 Monoacylglycerol lipase ABHD12 Oxidized phosphatidylserine lipase ABHD12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein depalmitoylation	ISO
lipid metabolic process	IEA
phosphatidylserine catabolic process	ISS
phosphatidylserine catabolic process	ISO
phosphatidylserine catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation

protein depalmitoylation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
phospholipase activity	ISS
phospholipase activity	ISO
lysophospholipase activity	ISS
lysophospholipase activity	ISO
lysophospholipase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity

lysophospholipase activity

acylglycerol lipase activity

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

carboxylic ester hydrolase activity [inference]

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydrolase

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
acylglycerol lipase activity
monoacylglycerol catabolic process
phosphatidylserine catabolic process

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Alpha/beta hydrolase fold-1

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP013586
Gene Name: abhydrolase domain containing 12

Ortholog

Displaying entries **11 - 20** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100057168		HORSE20908
Xenopus tropicalis	100216158	Xenbase:XB-GENE-990130
Taeniopygia guttata	100230632		TAEGU22205
Callithrix jacchus	100409959		CALJA34841
Pongo abelii	100449601		PONAB20265
Anolis carolinensis	100558062		ANOCA01930
Sus scrofa	100621636		PIGXX11384
Loxodonta africana	100670049		LOXAF12851
Oreochromis niloticus	100703483		ORENI12338
Cavia porcellus	100729841		CAVPO04961

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements