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acrosin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:126

Annotation

Keyword

Disease variant
Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P10323

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
binding of sperm to zona pellucida	IEA
response to steroid hormone	IEA
acrosome reaction	IBA IMP TAS	2550339 37004249
activation of adenylate cyclase activity	IDA	3880736
penetration of zona pellucida	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

acrosome matrix dispersal

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

acrosome matrix dispersal

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

acrosome matrix dispersal

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

acrosome matrix dispersal

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

reproductive process [inference]

fertilization [inference]

single fertilization

sperm-egg recognition [inference]

binding of sperm to zona pellucida

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

multi-multicellular organism process [inference]

penetration of zona pellucida

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone

response to organic cyclic compound [inference]

response to steroid hormone

response to lipid [inference]

response to steroid hormone

biological regulation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acrosomal matrix	TAS	12398221
protein-containing complex	IDA	7521127
Golgi-associated vesicle	IEA
extracellular region	TAS
nucleus	HDA	21630459

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
fucose binding	ISS
amidase activity	ISS
protein binding	IPI	15950651 7521127
zinc ion binding	NAS	6815104
DNA binding	NAS	1937464

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

amidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

enzyme binding [inference]

protease binding

carbohydrate binding [inference]

monosaccharide binding [inference]

small molecule binding [inference]

monosaccharide binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Trypsin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **11 - 20** of 33 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100406660			CALJA19056
Pongo abelii	100448292	9601_0:005022
Xenopus tropicalis	100497443		Xenbase:XB-GENE-5892360
Nomascus leucogenys	100586140			NOMLE33984
Otolemur garnettii	100963151			OTOGA17259
Pan paniscus	100979160	9597_0:0053fe		PANPA24180
Saimiri boliviensis boliviensis	101047167			SAIBB20952
Felis catus	101083949			FELCA17268
Gorilla gorilla gorilla	101144239	9595_0:0054a3		GORGO23740
Mustela putorius furo	101682369			MUSPF03591