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proprotein convertase subtilisin/kexin type 6

Summary

Gene Symbol

PCSK6

Organism

Homo sapiens (human)

External Links

NCBI Gene

5046

PubChem

5046

Alliance of Genome Resources

HGNC:8569

JoGo

PCSK6

TogoVar

PCSK6

Annotation

Keyword

Alternative splicing
Calcium
Cleavage on pair of basic residues
Endoplasmic reticulum
Glycoprotein
Membrane
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q59H04	Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Subtilisin/kexin-like protease PACE4
A2RQD9
P29122	Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Subtilisin/kexin-like protease PACE4
H7BXT3

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
zygotic determination of anterior/posterior axis, embryo	IEA
determination of left/right symmetry	IEA
glycoprotein metabolic process	IDA	8218226
protein processing	IDA	8218226 9242664 9738469
peptide hormone processing	IDA	9242664

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

export from cell [inference]

secretion by cell

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

anterior/posterior axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

embryonic pattern specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

neurotrophin production [inference]

nerve growth factor production

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell

export from cell [inference]

secretion by cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	8906861
extracellular space	IBA
endoplasmic reticulum	IEA
Golgi lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
endopeptidase activity	TAS
endopeptidase activity	IDA	9242664
serine-type endopeptidase activity	IDA	8218226 8615794 8906861
serine-type endopeptidase activity	IBA
protein binding	IPI	16433634 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type 6

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying entries **1 - 10** of 15 in total

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InterPro
EGF-like domain
Furin-like repeat
Galactose-binding-like domain superfamily
Growth factor receptor cysteine-rich domain superfamily
Kexin/furin catalytic domain
P domain
PLAC
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements