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platelet activating factor acetylhydrolase 1b regulatory subunit 1

Summary

Gene Symbol

PAFAH1B1

Aliases

LIS1
NudF
PAFAH
lissencephaly-1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5048

HGNC

8574

KEGG Gene ID

hsa:5048

PubChem

5048

Alliance of Genome Resources

HGNC:8574

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Coiled coil
Cytoskeleton
Developmental protein
Differentiation
Disease variant
Lipid degradation
Lissencephaly
Membrane
Microtubule
Mitosis
Neurogenesis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transport
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P43034	Lissencephaly-1 protein PAF acetylhydrolase 45 kDa subunit PAF-AH alpha
A0A6Q8PFU3	Lissencephaly-1 protein PAF acetylhydrolase 45 kDa subunit PAF-AH alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 58 in total

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GO Term	Evidence Code	PMID
establishment of mitotic spindle orientation	IMP	11056532
establishment of mitotic spindle orientation	IBA
microtubule cytoskeleton organization	ISS	10729324
ameboidal-type cell migration	IEA
acrosome assembly	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

myeloid leukocyte migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

platelet activating factor metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

small molecule metabolic process [inference]

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

organonitrogen compound metabolic process [inference]

platelet activating factor metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

cytoplasmic microtubule organization [inference]

cortical microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in establishment of planar polarity

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

microtubule sliding

microtubule organizing center organization

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cellular process involved in reproduction in multicellular organism [inference]

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebral cortex neuron differentiation

cell development [inference]

germ cell development

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

bone cell development [inference]

osteoclast development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration

neuron migration

leukocyte migration [inference]

myeloid leukocyte migration

cell division [inference]

stem cell division

cellular localization [inference]

intracellular transport [inference]

nuclear migration

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

maintenance of location in cell [inference]

maintenance of organelle location [inference]

maintenance of centrosome location

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

microtubule organizing center localization [inference]

centrosome localization [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

cytoplasmic microtubule organization [inference]

cortical microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in establishment of planar polarity

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cortical microtubule organization

vesicle organization [inference]

secretory granule organization [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

cellular component disassembly [inference]

membrane disassembly [inference]

nuclear membrane disassembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corpus callosum morphogenesis

microtubule organizing center organization

membrane organization [inference]

membrane disassembly [inference]

nuclear membrane disassembly

nuclear membrane organization [inference]

nuclear membrane disassembly

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

export from cell [inference]

secretion by cell [inference]

protein secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

cellular process involved in reproduction in multicellular organism [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

transmission of nerve impulse

cognition [inference]

learning or memory

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity [inference]

establishment of planar polarity of embryonic epithelium

animal organ morphogenesis [inference]

brain morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corpus callosum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

layer formation in cerebral cortex

anatomical structure development [inference]

cell development [inference]

germ cell development

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

bone cell development [inference]

osteoclast development

cochlea development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebral cortex neuron differentiation

cell development [inference]

germ cell development

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

neuron development [inference]

inner ear receptor cell development [inference]

auditory receptor cell development

bone cell development [inference]

osteoclast development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

nuclear migration

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

organic substance transport [inference]

protein transport [inference]

protein secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of centrosome localization

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of centrosome localization

organelle transport along microtubule [inference]

vesicle transport along microtubule

maintenance of location [inference]

maintenance of location in cell [inference]

maintenance of organelle location [inference]

maintenance of centrosome location

organelle localization [inference]

nucleus localization [inference]

nuclear migration

vesicle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of centrosome localization

organelle transport along microtubule [inference]

vesicle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

nuclear migration

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

retrograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

microtubule organizing center localization [inference]

centrosome localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of embryonic development

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of embryonic development

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of developmental process [inference]

positive regulation of embryonic development

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

positive regulation of embryonic development

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

negative regulation of neuron projection development

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of embryonic development

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

positive regulation of embryonic development

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
astral microtubule	IDA	11940666
kinetochore	IDA	11056532 11889140 11940666
kinetochore	IBA
nuclear envelope	IDA	11940666
nuclear envelope	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex

kinesin complex

catalytic complex [inference]

1-alkyl-2-acetylglycerophosphocholine esterase complex

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

organelle membrane [inference]

nuclear membrane

cell junction [inference]

synapse [inference]

cell leading edge

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

neuron projection

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule [inference]

astral microtubule

cytoplasmic microtubule

astral microtubule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10931877 11163258 11940666 16754861 20133715 20360068 22159412 27173435 28514442 29961565 31413325 33961781 38547289
microtubule binding	ISS	10729324
heparin binding	ISS	8028668
dynactin binding	ISS	11056532
identical protein binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

microtubule plus-end binding

dynactin binding

enzyme binding [inference]

phospholipase binding

protein dimerization activity [inference]

protein heterodimerization activity

phosphoprotein binding

protein-containing complex binding [inference]

dynein complex binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

putative

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
G-protein beta WD-40 repeat
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Human Protein Atlas

ENSG00000007168

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16794

Name

platelet-activating factor acetylhydrolase IB subunit alpha

References

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources
DOID:0112237	lissencephaly 1	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **31 - 40** of 78 in total

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HPO ID	HPO Term
HP:0001374	Congenital hip dislocation
HP:0001510	Growth delay
HP:0001539	Omphalocele
HP:0001561	Polyhydramnios
HP:0001626	Abnormality of the cardiovascular system
HP:0002007	Frontal bossing
HP:0002079	Hypoplasia of the corpus callosum
HP:0002119	Ventriculomegaly
HP:0002120	Cerebral cortical atrophy
HP:0002123	Generalized myoclonic seizure

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:95232	lissencephaly due to LIS1 mutation
ORPHA:531	Miller-Dieker lissencephaly syndrome
OMIM:607432	lissencephaly due to LIS1 mutation
ORPHA:217385	chromosome 17p13.3 duplication syndrome

PubChem Disease

GHR Health Conditions

MedGen Diseases

Lissencephaly due to LIS1 mutation

OMIM Phenotypes

LISSENCEPHALY 1; LIS1

KEGG Diseases

Lissencephaly

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001247
Gene Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Ortholog

Displaying entries **1 - 10** of **122** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5048	Xenbase:XB-GENE-1002843
Mus musculus	18472		MOUSE07373
Rattus norvegicus	83572		RATNO00544
Danio rerio	394246		DANRE08802
Danio rerio	394247		DANRE21776
Sus scrofa	397482		PIGXX03082
Pan troglodytes	454422		PANTR13221
Canis lupus familiaris	480656		CANLF19169
Macaca mulatta	574255		MACMU15112
Monodelphis domestica	100019365		MONDO15968

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements