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peroxiredoxin 1

Summary

Gene Symbol

PRDX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5052

PubChem

5052

Alliance of Genome Resources

HGNC:9352

JoGo

PRDX1

TogoVar

PRDX1

Annotation

Keyword

3D-structure
Acetylation
Antioxidant
Cytoplasm
Direct protein sequencing
Disulfide bond
Isopeptide bond
Peroxidase
Phosphoprotein
Proteomics identification
Redox-active center
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q06830	Natural killer cell-enhancing factor A Proliferation-associated gene protein Thioredoxin peroxidase 2 Thioredoxin-dependent peroxide reductase 2 Thioredoxin-dependent peroxiredoxin 1
A0A384NPQ2	Thioredoxin peroxidase 2 Thioredoxin-dependent peroxide reductase 2 Thioredoxin-dependent peroxiredoxin 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	8089076
response to oxidative stress	IBA
canonical NF-kappaB signal transduction	IEA
cell population proliferation	TAS	8089076
removal of superoxide radicals	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

myeloid cell homeostasis [inference]

erythrocyte homeostasis

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

signal transduction [inference]

intracellular signal transduction [inference]

canonical NF-kappaB signal transduction

cell population proliferation

fibroblast proliferation

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular response to stimulus [inference]

cellular response to stress

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

natural killer cell activation

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis [inference]

erythrocyte homeostasis

developmental process [inference]

anatomical structure development [inference]

system development [inference]

skeletal system development

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis [inference]

erythrocyte homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

cellular response to stimulus [inference]

cellular response to stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

canonical NF-kappaB signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

regulation of non-canonical NF-kappaB signal transduction

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	HDA	22664934 23580065
nucleus	IDA	17603937
nucleus	HDA	21630459
cytoplasm	IDA	17603937
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
peroxidase activity	TAS
peroxidase activity	IDA	11986303
protein binding	IPI	15105503 17909037 18172504 19369943 21044950 21969592 21988832 23386615 27607350 28671123 32814053 33961781
thioredoxin peroxidase activity	IDA	18606987

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

binding [inference]

protein binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

antioxidant activity [inference]

peroxidase activity

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxiredoxin

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
antioxidant activity
cellular oxidant detoxification
oxidoreductase activity
peroxiredoxin activity

Displaying **all 5** entries
InterPro
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Peroxiredoxin, AhpC-type
Peroxiredoxin, C-terminal
Thioredoxin domain
Thioredoxin-like superfamily