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endoplasmic reticulum oxidoreductase 1 alpha

Summary

Gene Symbol

Ero1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

50527

PubChem

50527

Alliance of Genome Resources

MGI:1354385

Annotation

Keyword

Apoptosis
Cell projection
Disulfide bond
Electron transport
Endoplasmic reticulum
FAD
Glycoprotein
Golgi apparatus
Membrane
Oxidoreductase
Phosphoprotein
Redox-active center
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8R180	Endoplasmic reticulum oxidoreductase alpha Endoplasmic reticulum oxidoreductin-1-like protein Oxidoreductin-1-L-alpha
Q4FK57	Endoplasmic reticulum oxidoreductase alpha Oxidoreductin-1-L-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 24 in total

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GO Term	Evidence Code	PMID
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI	22981861
L-ascorbic acid metabolic process	IMP	28106121
protein maturation by protein folding
extracellular matrix organization	IGI	22981861
collagen fibril organization	IMP	28106121

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

protein maturation by protein folding

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid metabolic process

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

protein maturation by protein folding

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

protein maturation by protein folding

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organic cyclic compound metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

lactone metabolic process [inference]

L-ascorbic acid metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

protein maturation by protein folding

cellular process [inference]

protein folding

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

endoplasmic reticulum unfolded protein response

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid metabolic process

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to oxidative stress

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

endoplasmic reticulum unfolded protein response

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISO	10671517
endoplasmic reticulum membrane	IBA
Golgi lumen	ISS
Golgi lumen	ISO
dendrite	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-disulfide reductase activity	IDA	20308425
protein-disulfide reductase activity	IBA
oxidoreductase activity	ISO
oxidoreductase activity	IDA	15601821
thiol oxidase activity	IEA