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platelet derived growth factor subunit A

Summary

Gene Symbol

PDGFA

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 505908
PubChem: 505908

Annotation

Keyword

Cleavage on pair of basic residues
Developmental protein
Disulfide bond
Glycoprotein
Growth factor
Mitogen
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q2KJ15	Platelet-derived growth factor A chain Platelet-derived growth factor alpha polypeptide

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA	30032202
response to wounding
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
regulation of smooth muscle cell migration

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor-beta signaling pathway [inference]

regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

regulation of metanephric mesenchymal cell migration [inference]

regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cell division

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor-beta signaling pathway [inference]

regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein autophosphorylation [inference]

positive regulation of protein autophosphorylation

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

regulation of fibroblast proliferation [inference]

positive regulation of fibroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein autophosphorylation

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cell division

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phospholipid metabolic process [inference]

negative regulation of phospholipid biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of cell division [inference]

positive regulation of cell division

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

regulation of metanephric mesenchymal cell migration [inference]

regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of metanephric mesenchymal cell migration [inference]

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
cell surface
membrane	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
platelet-derived growth factor receptor binding	IEA	30032202
collagen binding
growth factor activity	IEA	22301074
protein homodimerization activity

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

growth factor activity

growth factor receptor binding [inference]

platelet-derived growth factor receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-containing complex binding [inference]

collagen binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

platelet-derived growth factor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
growth factor activity
platelet-derived growth factor receptor binding
platelet-derived growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of cell migration
positive regulation of cell population proliferation
positive regulation of protein autophosphorylation

Displaying **all 4** entries
InterPro
Cystine-knot cytokine
PDGF/VEGF domain
Platelet-derived growth factor, N-terminal
Platelet-derived growth factor, conserved site

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	5154	HUMAN87506
Mus musculus	18590	MOUSE46851
Rattus norvegicus	25266	RATNO05374
Danio rerio	378480	DANRE50241
Macaca mulatta	707725	MACMU32316
Pan troglodytes	740202	PANTR48302
Danio rerio	767790	DANRE30799
Monodelphis domestica	100020951	MONDO28219
Taeniopygia guttata	100222155	TAEGU04863
Pongo abelii	100440212	PONAB00148

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements