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ATPase H+ transporting V0 subunit a4

Summary

Gene Symbol

ATP6V0A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

50617

PubChem

50617

Alliance of Genome Resources

HGNC:866

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Hydrogen ion transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HBG4	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IMP	12414817
synaptic vesicle lumen acidification	IEA
renal tubular secretion	IMP	12414817
intracellular pH reduction	NAS	32001091
vacuolar acidification	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

multicellular organismal process [inference]

ossification

system process [inference]

renal system process [inference]

renal tubular secretion

excretion [inference]

renal tubular secretion

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

neuron cellular homeostasis [inference]

synaptic vesicle lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

monoatomic cation homeostasis [inference]

regulation of pH

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

establishment of localization in cell [inference]

synaptic vesicle lumen acidification

biological regulation [inference]

regulation of pH

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

vacuolar acidification

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IEA
apical plasma membrane	IDA	10973252 12649290 15800125
plasma membrane	IBA IDA NAS	17360703 32001091
endosome	ISS
vacuolar proton-transporting V-type ATPase complex	IBA IDA	10973252

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

proton-transporting two-sector ATPase complex, proton-transporting domain [inference]

proton-transporting V-type ATPase, V0 domain [inference]

vacuolar proton-transporting V-type ATPase, V0 domain

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

apical part of cell

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12649290 18632794 32814053
proton-transporting ATPase activity, rotational mechanism	IEA
ATPase binding	IBA IPI	17360703

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

binding [inference]

protein binding

enzyme binding [inference]

ATPase binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

C: Energy production and conversion
D: Cell cycle control, cell division, chromosome partitioning
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATPase binding
monoatomic ion transport
proton-transporting ATPase activity, rotational mechanism
vacuolar acidification

Displaying **all 2** entries
InterPro
ATPase, V0 complex, subunit 116kDa, eukaryotic
V-type ATPase, V0 complex, 116kDa subunit family

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110942	autosomal recessive osteopetrosis 1	Alliance of Genome Resources
DOID:14219	renal tubular acidosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	34587	FB:FBgn0032373
Drosophila melanogaster	42214	FB:FBgn0038613
Drosophila melanogaster	42216	FB:FBgn0028670
Drosophila melanogaster	43442	FB:FBgn0028671
Mus musculus	140494	MGI:2153480	MOUSE50608
Caenorhabditis elegans	174743	WB:WBGene00006915
Caenorhabditis elegans	176257	WB:WBGene00006768
Caenorhabditis elegans	177626	WB:WBGene00006914
Caenorhabditis elegans	178219	WB:WBGene00006916
Rattus norvegicus	296981	RGD:1305055	RATNO30774