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regulator of G-protein signaling 6

Summary

Gene Symbol

Rgs6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

50779

PubChem

50779

Alliance of Genome Resources

MGI:1354730

Annotation

Keyword

Cell membrane
Cytoplasm
Nucleus
Proteomics identification
Reference proteome
Signal transduction inhibitor

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9Z2H2
A0A087WNZ9
Q3UTM5

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS	11342430
G protein-coupled receptor signaling pathway	IBA
regulation of G protein-coupled receptor signaling pathway	IEA
negative regulation of signal transduction	IEA
intracellular signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

regulation of neuron differentiation [inference]

positive regulation of neuron differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

regulation of cellular process [inference]

signal transduction [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

regulation of neuron differentiation [inference]

positive regulation of neuron differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of neuron differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IBA
cytosol	ISS
cytosol	ISO
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
GTPase activator activity	ISS
GTPase activator activity	ISO
GTPase activator activity	TAS	11342430
GTPase activator activity	IBA
protein binding	IPI	15897264 22689652

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein signaling regulator

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of G protein-coupled receptor signaling pathway

Displaying entries **1 - 10** of 11 in total

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InterPro
DEP domain
G-protein gamma-like domain superfamily
G-protein gamma-like domain
RGS domain superfamily
RGS domain
RGS, subdomain 2
Regulator of G protein signaling 6/7/9/11
Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily
Regulator of G-protein signalling, DHEX domain
Winged helix DNA-binding domain superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9628		HUMAN20085
Drosophila melanogaster	24012	FB:FBgn0024941
Xenopus tropicalis	32674	Xenbase:XB-GENE-954519
Xenopus tropicalis	50779	Xenbase:XB-GENE-954519
Rattus norvegicus	54295		RATNO35364
Pan troglodytes	453009		PANTR09090
Canis lupus familiaris	480380		CANLF18052
Danio rerio	562667		DANRE20253
Macaca mulatta	694620		MACMU41211
Monodelphis domestica	100024815		MONDO01615