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phosphodiesterase 11A

Summary

Gene Symbol

PDE11A

Aliases

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Organism

Homo sapiens (human)

External Links

NCBI Gene

50940

HGNC

8773

PubChem

50940

Alliance of Genome Resources

HGNC:8773

JoGo

PDE11A

TogoVar

PDE11A

Annotation

Keyword

Allosteric enzyme
Alternative splicing
Cushing syndrome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
cAMP
cGMP

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HCR9	cAMP and cGMP phosphodiesterase 11A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signal transduction	TAS	10725373
negative regulation of cGMP-mediated signaling	IBA
cAMP-mediated signaling	IBA
negative regulation of cAMP-mediated signaling

GO Hierarchy

biological process

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cGMP-mediated signaling [inference]

negative regulation of cGMP-mediated signaling

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cGMP-mediated signaling [inference]

negative regulation of cGMP-mediated signaling

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of cGMP-mediated signaling [inference]

negative regulation of cGMP-mediated signaling

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cyclic-nucleotide phosphodiesterase activity	NAS	10906126
3',5'-cyclic-nucleotide phosphodiesterase activity	TAS	10725373
3',5'-cyclic-AMP phosphodiesterase activity	IBA
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	IEA
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA	19689430

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-GMP phosphodiesterase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

cGMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

ion binding [inference]

anion binding [inference]

cGMP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

cGMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000128655

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:16957

H₂O + 3',5'-cyclic GMP

H⁺ + GMP

Enzyme

3.1.4.35

PMID

RHEA:25277

H₂O + 3',5'-cyclic AMP

H⁺ + AMP

Enzyme

3.1.4.53

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070547	primary pigmented nodular adrenocortical disease 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **41 - 50** of 73 in total

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HPO ID	HPO Term
HP:0002890	Thyroid carcinoma
HP:0002894	Neoplasm of the pancreas
HP:0002895	Papillary thyroid carcinoma
HP:0002920	Decreased circulating ACTH concentration
HP:0003118	Increased circulating cortisol level
HP:0003466	Paradoxical increased cortisol secretion on dexamethasone suppression test
HP:0003621	Juvenile onset
HP:0004324	Increased body weight
HP:0004944	Dilatation of the cerebral artery
HP:0005585	Spotty hyperpigmentation