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Guidelines

MIRAGE

SH3 and multiple ankyrin repeat domains 1

Summary

Gene Symbol

SHANK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

50944

PubChem

50944

Alliance of Genome Resources

HGNC:15474

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Cytoplasm
Differentiation
Methylation
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
H9KV90
Q9Y566	Somatostatin receptor-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
long-term memory	ISS
associative learning	ISS
adult behavior	IMP	22503632
negative regulation of actin filament bundle assembly	ISS
social behavior	IMP	22503632

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component assembly [inference]

protein-containing complex assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendritic spine morphogenesis

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

synapse organization [inference]

synapse maturation

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

protein-containing complex organization [inference]

protein-containing complex assembly

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

habituation

memory [inference]

long-term memory

sensory processing [inference]

determination of affect

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

nonassociative learning [inference]

habituation

memory [inference]

long-term memory

chemosensory behavior [inference]

olfactory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

developmental maturation [inference]

synapse maturation

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

righting reflex

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of AMPA receptor activity

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of AMPA receptor activity

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of AMPA receptor activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	ISS
plasma membrane	IDA
postsynaptic density	ISS
postsynaptic density	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein binding	ISS
protein binding	IPI	10551867 11583995 30126976 33436498 34835087
SH3 domain binding	ISS
synaptic receptor adaptor activity	ISS
synaptic receptor adaptor activity	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

neuropeptide receptor binding [inference]

somatostatin receptor binding

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

protein domain specific binding [inference]

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

synaptic receptor adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SH3 and multiple ankyrin repeat domains 1

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ionotropic glutamate receptor binding
synaptic receptor adaptor activity

Displaying **all 9** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
PDZ domain 6
PDZ domain
PDZ superfamily
SH3 domain
SH3-like domain superfamily
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025