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sclerostin
Summary
- Gene Symbol
-
- SOST
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Heparin-binding
- Reference proteome
- Signal
- Wnt signaling pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9BQB4 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| ossification | ||
| response to mechanical stimulus | ||
| negative regulation of Wnt signaling pathway | ||
| negative regulation of ossification | ||
| BMP signaling pathway |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| Golgi apparatus | ||
| protein-containing complex | ||
| collagen-containing extracellular matrix |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| heparin binding | ||
| carbohydrate binding | ||
| BMP binding | ||
| DNA-binding transcription factor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- sclerostin
- Functional Category
-
- G: Carbohydrate transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| BMP binding |
| heparin binding |
| ossification |
| InterPro |
|---|
| Cystine knot, C-terminal |
| Cystine-knot cytokine |
| Sclerostin/Sclerostin domain-containing protein 1 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060251 | sclerosteosis | |
| DOID:0060756 | sclerosteosis 1 | |
| DOID:0080807 | autosomal dominant craniodiaphyseal dysplasia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 50964 | ZFIN:ZDB-GENE-110411-139 | ||
| 74499 | ZFIN:ZDB-GENE-110411-139 | MOUSE04769 | |
| 80722 | ZFIN:ZDB-GENE-110411-139 | RATNO02986 | |
| 490948 | CANLF18658 | ||
| 713617 | MACMU15497 | ||
| 740261 | PANTR13781 | ||
| 100000500 | DANRE46026 | ||
| 100009840 | MONDO13863 | ||
| 100086070 | ORNAN03342 | ||
| 100223624 | TAEGU15378 |
