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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
aconitase 2
Summary
- Gene Symbol
-
- ACO2
- Aliases
-
- ACONM
- aconitate hydratase, mitochondrial
- mitochondrial aconitase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 4Fe-4S
- Acetylation
- Direct protein sequencing
- Disease variant
- Lyase
- Mitochondrion
- Neurodegeneration
- Phosphoprotein
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99798 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| mitochondrial matrix |
|
|
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| 4 iron, 4 sulfur cluster binding | ||
| 3 iron, 4 sulfur cluster binding | ||
| aconitate hydratase activity | ||
| iron ion binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110535 | autosomal recessive nonsyndromic deafness 9 | |
| DOID:0110536 | autosomal recessive nonsyndromic deafness 91 | |
| DOID:0110537 | autosomal recessive nonsyndromic deafness 93 | |
| DOID:0110538 | autosomal recessive nonsyndromic deafness 96 | |
| DOID:0110539 | autosomal recessive nonsyndromic deafness 97 | |
| DOID:0110540 | autosomal recessive nonsyndromic deafness 98 | |
| DOID:0110541 | autosomal dominant nonsyndromic deafness 1 | |
| DOID:0110542 | autosomal dominant nonsyndromic deafness 10 | |
| DOID:0110543 | autosomal dominant nonsyndromic deafness 11 | |
| DOID:0110544 | autosomal dominant nonsyndromic deafness 12 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000648 | Optic atrophy |
| HP:0001251 | Ataxia |
| HP:0001252 | Hypotonia |
| HP:0001265 | Hyporeflexia |
| HP:0001272 | Cerebellar atrophy |
| HP:0001284 | Areflexia |
| HP:0001508 | Failure to thrive |
| HP:0002069 | Bilateral tonic-clonic seizure |
| HP:0002079 | Hypoplasia of the corpus callosum |
| HP:0002120 | Cerebral cortical atrophy |
| Disease ID | Disease Name |
|---|---|
| OMIM:614559 |
|
| OMIM:616289 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 176121 | WB:WBGene00000041 | ||
| 41326 | FB:FBgn0037862 | ||
| 44149 | FB:FBgn0010100 | ||
| 103189232 | CALMI40993 | ||
| 322670 | ZFIN:ZDB-GENE-030131-1390 | DANRE45736 | |
| 103029821 | ASTMX07738 | ||
| 103031515 | ASTMX14322 | ||
| 108273913 | ICTPU05126 | ||
| 113574872 | ELEEL17037 | ||
| 113584853 | ELEEL34038 |
